A science advisory from the American Heart Association recommended that prescription n-3 fatty acids (eicosapentaenoic acid [EPA]+docosahexaenoic acid [DHA] or EPA-only) at a dose of 4 g/d (>3 g/d total EPA+DHA) are an effective and safe option for reducing triglycerides as monotherapy or as an adjunct to other lipid-lowering agents […]
Two US studies showed that more intensive blood pressure (BP) management was associated with less progression of cerebral small vessel ischemic diseaseand a greater decrease in total brain volume; BP patterns in midlife and late life may be associated with differing risks for incident dementia. The substudy of a randomized […]
A longitudinal population-based cohort study showed that higher 24-hour and nighttime blood pressure (BP) measurements were significantly associated with greater risks of death and a composite cardiovascular (CV) outcome. The study included 11 135 adults from Europe, Asia, and South America (median age, 54.7 years, 49.3% women) with baseline observations collected […]
A US retrospective cohort study concluded that both systolic and diastolic hypertension contribute significantly to cardiovascular risk. The study included 1.3 million adults in a general outpatient population. The burdens of systolic and diastolic hypertension each independently predicted adverse outcomes. In survival models, a continuous burden of systolic hypertension (≥140 […]
A US phase 2, multicenter, randomized controlled trial revealed that 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. From May, 2007, to Feb, 2010, the trial randomly assigned 218 participants (21–50 years, BMI 22·0–27·9 kg/m 2) to a 25% calorie restriction diet […]
A meta-analysis of recent randomized controlled trials and systematic reviews concluded that reduced salt intake, omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) use, and folate supplementation could reduce risk for some cardiovascular diseases (CVD). Combined calcium plus vitamin D might increase risk for stroke. The analysis selected 9 systematic reviews and […]
A prospective Chinese cohort study suggested a significant association between lower low-density lipoprotein cholesterol (LDL-C) and higher risk of intracerebral hemorrhage (ICH) when LDL-C was <70 mg/dL. The study included 96,043 participants (mean age 51.3 years) who were free of stroke, myocardial infarction, and cancer at baseline (2006). There were […]
A US randomized controlled trial showed that compared with nonmeat as the major protein source, diets high in saturated fatty acid (SFA) and/or meat result in higher concentrations of lipids and lipoproteins, indicating other effects of red meat consumption could contribute to adverse effects on the risk of cardiovascular disease […]
A systematic review and meta-analysis suggested that untreated white coat hypertension (WCH, isolated elevated office blood pressure [BP]), but not treated white coat effect (WCE, treated WCH), is associated with an increased risk for cardiovascular events and all-cause mortality. The analysis included 27 observational studies, comprising 25 786 participants with untreated […]
A US cross-sectional and prospective analysis suggested that increased variability in sleep duration and timing was associated with higher prevalence and incidence of metabolic abnormalities even after considering sleep duration and other lifestyle factors. Participants completed 7-day actigraphy from 2010 to 2013 and were prospectively followed throughout 2016 to 2017. […]