Cardiovascular Diseases


Update of Supplemental Vitamins and Minerals for CAD

An update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease (CVD) outcomes and all-cause mortality shows similar findings for preventive benefits from both folic acid and B vitamins for stroke, and an increased risk with niacin (with statin) for all-cause mortality. In […]


Alcohol Consumption Linked to AF Risk

A European cohort study revealed that even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of atrial fibrillation (AF). The study followed 107 845 individuals (median age 47.8 years, 48.3% men) from five community-based cohorts across Europe. The median alcohol consumption was 3 g/day. During median […]


Colchicine Reduced CAD Risk

A meta-analysis of randomized controlled trials concluded that colchicine treatment may reduce the risk of cardiovascular events in patients with coronary artery disease (CAD). The analysis included 5 randomized controlled trials with follow-up duration ≥6 months, comprising a total of 11,790 patients with CAD. Compared with placebo or no treatment, […]


Conservative Management Safer for Inpatient High BP

A US cohort study suggested that in the absence of evidence of end-organ damage, conservative management of inpatient high blood pressure (BP) was associated with improved outcomes compared with more intensive management. The study included 22 834 adults hospitalized for noncardiovascular diagnoses from January 1 to December 31, 2017 (mean age, […]


Blood Metabolites Linked to Stroke Risk

Ten metabolites from seven prospective cohort studies were found to be associated with risk of stroke. The studies included 1,791 incident stroke events among 38,797 participants. Independent of traditional risk factors including hypertension, diabetes, smoking, and body mass index, amino acid histidine (hazard ratio [HR] per standard deviation [SD] = […]


LDL-C Significance in ASCVD Challenged

Two studies suggest that low-density lipoprotein cholesterol (LDL-C) may not to be the main lipid contributor to atherosclerotic cardiovascular disease (ASCVD). The study in Spain included 6901 subjects in the high-risk primary prevention trial population (mean age: 67 years; body mass index: 30 kg/m2; 43% men; 48% with diabetes) with […]


Finerenone Reduced CV Events and CKD Progression

A randomized, double-blind, placebo-controlled trial in chronic kidney disease (CKD) and type 2 diabetes (T2D) concluded that treatment with finerenone reduced risks of CKD progression and cardiovascular (CV) events. Between September 2015 and June 2018, 5734 patients with CKD and T2D were randomly assigned in a 1:1 ratio to receive […]


Lipid Lowering Beneficial Regardless of Age

A contemporary primary prevention cohort study and a systematic review and meta-analysis showed that older people with elevated LDL cholesterol had higher absolute risk of atherosclerotic cardiovascular disease (CVD), and lipid lowering was as effective in reducing cardiovascular events as it was in younger ones. The cohort study included 13 779 […]


Proinflammatory Diet Linked to CVD

A prospective US study suggests that dietary patterns with a higher proinflammatory potential were associated with higher risk of cardiovascular disease (CVD). The study included 166,234 women and 43,911 men from 3 cohorts, with 5,291,518 person-years of follow-up. The inflammatory potential of diet was evaluated using a food-based empirical dietary […]


Time Course of LDL-C Linked to CVD Risk

A prospective study suggests that incident cardiovascular disease (CVD) event risk depends on the time course of cumulative prior exposure to low-density lipoprotein cholesterol (LDL-C), the younger the age of exposure accumulation, the greater risk increase. The study included 4,958 asymptomatic adults age 18 to 30 years enrolled from 1985 […]