A multicenter, open-label, randomized crossover trial with blinded endpoint assessment in Europe revealed that 4 weeks of treatment with amlodipine, losartan, or atenolol resulted in differential effects on cerebrovascular reactivity (CVR) in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) but not in patients with symptomatic […]
A US cohort study suggests that high blood pressure variability (BPV) can indicate increased incident dementia risk in older age. The study focused on 820 participants (mean age, 77.0 years; 58.0% females) with data of brain autopsy and midlife to late-life BP. A mean of 28.4 yearly SBP measurements were […]
A double-blind, double-dummy, randomized trial in European countries revealed that among patients with atrial high-rate episodes (AHREs) detected by implantable devices, anticoagulation with edoxaban led to a higher incidence of a composite of death or major bleeding but did not significantly improve efficacy outcomes. A total of 2536 patients 65 […]
A UK prospective cohort study in patients with symptoms suggestive of stable angina suggested that cardiac troponin predicts risk of myocardial infarction or cardiovascular death independent of cardiovascular risk factors and disease severity. The study included 4,240 patients (mean age 66 years, 33% female), coronary artery disease (CAD) was identified […]
A cohort study revealed that subclinical atrial fibrillation (AF) was common in heart failure (HF) patients with preserved ejection fraction (HFpEF) and mildly reduced ejection fraction (HFmrEF). The study included 367 patients with cardiac monitoring data at baseline and follow-up in a randomized clinical trial of atrial shunt therapy. The […]
The updated American guideline provides an evidence-based and patient-centered approach to management of patients with chronic coronary disease (CCD). The guideline is based on a comprehensive literature search from September 2021 to May 2022 and includes the following top take-home messages: Emphasis is on team-based, patient-centered care. Nonpharmacological therapies, including […]
The analysis of a UK cohort study suggests that a weekend warrior pattern of physical activity was associated with similarly lower risks of cardiovascular diseases (CVD) to regular activity. A total of 89 573 individuals (mean age, 62 years; 56% women) who underwent accelerometry were included. When stratified at the threshold […]
An analysis of data from international studies indicated that diets comprised of higher amounts of fruits, vegetables, nuts, legumes, and a moderate amount of fish and whole-fat dairy is associated with a lower risk of cardiovascular disease (CVD) and mortality in all world regions, especially in countries with lower income […]
An analysis of individual-level information of heart failure (HF) patients revealed that there was a left ventricular ejection fraction (LVEF) threshold of around 40% to 50% where the pattern of patient characteristics changed, and event rates began to increase compared with higher LVEF values. The analysis was performed on 33 699 […]
A systematic review and meta-analysis revealed that vegetarian and vegan diets were consistently associated with reduced concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (Apo B). The study included 30 randomized controlled trials published between 1980 and October 2022. Compared with omnivorous diets, the plant-based diets reduced […]