Smell Loss Linked to Depression

1 month ago

Subjective olfactory impairment (self-reported smell loss) is consistently associated with a higher likelihood of depression, whereas objectively measured olfactory impairment…

Accelerated Biological Aging Linked to Higher Cancer Risk

1 month ago

Accelerated biological aging was associated with a higher risk of early-onset solid cancers in young adults, particularly lung, gastrointestinal, and…

Testosterone Therapy Without Hypogonadism Linked to Higher Long-Term Cardiovascular Risk

1 month ago

Men who started testosterone therapy (TT) without evidence of hypogonadism had significantly higher long-term risks of major adverse cardiovascular events…

Lifestyle Intervention May Slow Early Cerebral Small-Vessel Injury

1 month ago

A secondary MRI analysis of the US POINTER randomized clinical trial found that a structured multidomain lifestyle intervention slowed the…

Shared and Region-Specific Dementia Risk Factors

1 month ago

Dementia risk factors vary substantially across countries, but they frequently cluster together in similar patterns worldwide, supporting both context-specific prevention…

Comparative Benefits and Risks of Anti-Obesity Drugs

2 months ago

A systematic review and network meta-analysis of 262 randomized trials involving 99,791 participants found that anti-obesity medications vary substantially in…

Early Mild Hypertrophic Cardiomyopathy May Still Carry Significant Cardiovascular Risk

2 months ago

Approximately 21% of patients with phenotypically mild hypertrophic cardiomyopathy (HCM) experienced major adverse cardiovascular events (MACE) during a mean follow-up…

High-Intensity Interval Exercise Reduces Energy Intake in Adults With Overweight or Obesity

2 months ago

A Danish randomized crossover trial found that a single session of high-intensity interval exercise (HIIE) significantly reduced immediate energy intake…

Proton Pump Inhibitor and Antibiotic Use May Reduce the Benefit of Immunotherapy in NSCLC

2 months ago

Baseline use of proton pump inhibitors (PPIs) and, to a lesser extent, antibiotics was associated with poorer outcomes in patients…

Progestogen Contraceptives Linked to Increased Meningioma Risk

2 months ago

A nationwide Danish study found that recent use of several progestogen-containing contraceptives—including cyproterone, desogestrel, drospirenone, gestodene, levonorgestrel, injectable medroxyprogesterone, and…

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