Updated US Guideline on Pharmacologic Prevention of Migraine in Adults

2 weeks ago

The US updated evidence-based recommendations provide clinicians with comprehensive guidance on when to initiate pharmacologic migraine prevention, how to select…

Catheter-Directed Thrombolysis Improves Outcomes in Intermediate-High–Risk Pulmonary Embolism

2 weeks ago

In patients with intermediate-high–risk acute pulmonary embolism, catheter-directed thrombolysis with alteplase plus anticoagulation significantly reduced the 7-day risk of death,…

Atorvastatin Prevents Cardiovascular Events in Older Adults without Prior Cardiovascular Disease

2 weeks ago

In a large randomized trial, atorvastatin 40 mg daily significantly reduced major cardiovascular events by 30% among community-dwelling adults aged…

Aficamten Improves Exercise Capacity and Health Status in Nonobstructive HCM

2 weeks ago

In patients with symptomatic nonobstructive hypertrophic cardiomyopathy (HCM), aficamten significantly improved exercise capacity and patient-reported health status compared with placebo…

DOACs Reduce Cardiovascular Events in Atrial Fibrillation at Intermediate Stroke Risk

2 weeks ago

In patients with atrial fibrillation at intermediate risk for stroke, direct oral anticoagulant (DOAC) therapy significantly reduced the 24-month risk…

Recombinant Shingles Vaccine Linked to Reduced Cardiovascular Risk

3 weeks ago

The recombinant shingles vaccine was associated with a 9% reduction in overall cardiovascular burden over 7 years among adults aged…

Multiday Heart Rate Rhythms Common in Young Adults

3 weeks ago

In a US retrospective observational cohort study of 623 young adults, significant infradian (multiday) heart rate rhythms were detected in…

Early-Life Sugar Restriction Linked to Lower Risk of Early-Onset Cancer

3 weeks ago

Early-life sugar restriction during pregnancy and infancy was associated with a 34% lower risk of early-onset cancer (diagnosed by age…

Domain-Specific Physical Activity and Dementia Risk

4 weeks ago

Higher levels of physical activity were associated with lower risks of all-cause dementia, Alzheimer’s disease, and vascular dementia, but the…

BMI and Waist Circumference Jointly Predict Mortality Risk in Older Adults

4 weeks ago

In US adults aged ≥65 years, overweight and class I–II obesity were associated with lower all-cause mortality risk, whereas high…

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