Mental Disorders

Proton Pump Inhibitor Use Linked to Dementia Risk in Older Adults

Proton pump inhibitor (PPI) use was modestly associated with incident dementia in older adults (pooled HR = 1.18), but the…

2 days ago

Antidepressants Differ in Efficacy and Acceptability in Long-Term Treatment of Major Depressive Disorder

Escitalopram, duloxetine, and agomelatine achieved higher sustained response rates than fluoxetine, while escitalopram and duloxetine also showed lower all-cause discontinuation,…

3 days ago

Circadian Depression Subtype Linked to More Severe Symptoms and Poorer Antidepressant Response

A circadian subtype of depression is associated with earlier disease onset, more severe clinical features, poorer response to commonly prescribed…

3 weeks ago

Frequent and Unintentional Daytime Napping Linked to Higher Dementia Risk

A longitudinal study of 995 U.S. older adults found that frequent and unintentional daytime napping was associated with an increased…

4 weeks ago

Carotid Revascularization Does Not Improve Cognition in Asymptomatic Severe Carotid Stenosis

In patients with severe asymptomatic carotid artery stenosis, carotid revascularization—either carotid artery stenting (CAS) or carotid endarterectomy (CEA)—added to intensive…

2 months ago

Early Brain Ageing Linked to the Gut–Brain Axis

Higher functional-connectivity-derived brain age deviation was consistently associated with poorer cognitive performance—particularly working memory and executive function—and greater depressive symptoms…

2 months ago

Domain-Specific Physical Activity and Dementia Risk

Higher levels of physical activity were associated with lower risks of all-cause dementia, Alzheimer’s disease, and vascular dementia, but the…

3 months ago

Midlife Vascular Health Linked to Up to 12.6 More Dementia-Free Years

Maintaining optimal vascular health in midlife was associated with up to 12.6 additional years of life free from dementia between…

3 months ago

Limiting Sugar in the First 1,000 Days of Life May Reduce Dementia Risk Decades Later

Restricting sugar intake during the first 1,000 days from conception was associated with a lower risk of dementia, delayed disease…

4 months ago

WHO Dementia Prevention Guidelines Updated

To reduce the risk of cognitive decline and/or dementia specifically, the WHO just released updated guidance and dementia-specific recommendations: cognitive…

4 months ago

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