Extended follow-up of three major trials consistently shows that an initial invasive strategy does not improve long-term survival or reduce…
Targeting a systolic blood pressure (BP) of less than 120 mm Hg lowered the incidence of major cardiovascular events compared…
In patients with type 2 diabetes (T2D) and high cardiovascular risk, targeting a systolic blood pressure (BP) of less than…
Among older adults with at least two chronic conditions but no known cardiovascular disease, discontinuing statin therapy was noninferior to…
Two randomized, placebo-controlled trials of targeted therapies—ziltivekimab, a monoclonal antibody neutralizing interleukin-6, and pelacarsen, an antisense oligonucleotide lowering lipoprotein(a)—both failed…
Among US Medicare beneficiaries, colder ambient temperatures were associated with increased heart failure hospitalizations while warmer temperatures were not, and…
In the 10-year extended follow-up of the DECISION-CTO trial, an initial strategy of percutaneous coronary intervention (PCI) for chronic total…
In a randomized, open-label, noninferiority trial, a coronary computed tomographic angiography (CCTA)–guided percutaneous coronary intervention (PCI) strategy was noninferior to…
A randomized trial found that left bundle-branch area pacing (LBBAP) significantly reduced the risk of major clinical events, particularly heart…
Familial hypercholesterolaemia (FH) is associated with reduced thymic output and accelerated thymic ageing, while statin treatment may help preserve immune…
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