Mental Disorders

BD’s Polygenic Genetic Architecture

A genome-wide study of bipolar disorder (BD) revealed an extensive polygenic genetic architecture of the disease, implicate brain calcium channels and neurotransmitter function in BD etiology, and confirmed that BD is part of a spectrum of highly correlated psychiatric and mood disorders. The study included 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 822 variants in an additional 9,412 cases and 137,760 controls. In the combined analysis, 30 loci were genome-wide significant, including 20 newly identified loci. The significant loci contain genes encoding ion channels, neurotransmitter transporters and synaptic components. Pathway analysis revealed nine significantly enriched gene sets, including regulation of insulin secretion and endocannabinoid signaling. BD is a multifactorial disorder characterized by recurrent episodes of mania and depression that affect thought, perception, emotion and social behavior, and has two main clinical subtypes, BD1 is strongly genetically correlated with schizophrenia, driven by psychosis, whereas BD2 is more strongly correlated with major depressive disorder. Source: https://www.nature.com/

hyangiu

Recent Posts

Mediterranean Diet May Slow Atherosclerosis Progression and Prevent CHD

A Spanish secondary prevention study suggested that Mediterranean diet might reduce neutrophil levels and slow…

4 days ago

2024 Strategies and Criteria for the Diagnosis and Management of Myocarditis

Top 10 key takeaway points of the report of the American College of Cardiology Solution…

2 weeks ago

Irregular Sleep Linked to Higher CVD Risk

A UK device-based prospective study suggested that irregular sleep was associated with higher risk of…

4 weeks ago

Intensive BP Control Benefits T2D Patients

A Chinese parallel design, randomized clinical trial showed that the incidence of major cardiovascular events…

1 month ago

Early-Life Sugar Restriction Protective on T2D and High Blood Pressure

A study comparing UK adults conceived just before or after sugar rationing ended found that…

1 month ago

Cold Weather Linked to Higher MI Risk

A Chinese nationwide case-crossover study revealed that lower temperatures were associated with higher risks of…

2 months ago

This website uses cookies.