A meta-analysis of genome-wide association studies of depression identified 102 independent variants, 269 genes, and 15 genesets associated with depression, including both genes and gene pathways associated with synaptic structure and neurotransmission. The analysis included 807,553 individuals (246,363 cases and 561,190 controls). An enrichment analysis provided further evidence of the importance of prefrontal brain regions. In an independent replication sample of 1,306,354 individuals (414,055 cases and 892,299 controls), 87 of the 102 associated variants were significant after multiple testing correction. These findings advance our understanding of the complex genetic architecture of depression and provide several future avenues for understanding etiology and developing new treatment approaches. Source: https://www.nature.com/
A recent article explored the science and skepticism surrounding seed oils. These oils—extracted from sources…
A Canadian study of adults with high blood pressure (BP) found no difference in health…
Two randomized, controlled trials evaluated the efficacy and safety of obicetrapib, an oral cholesteryl ester…
A UK longitudinal associations study revealed that hyperlipidemias and inflammation independently and together raise the…
A study shows that eating a lot of highly processed foods is likely causing a…
Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular…
This website uses cookies.