Endotyping-informed therapy guided by adenosine stress cardiovascular MRI revised diagnoses in over half of patients with chest pain and unobstructed coronary arteries and significantly improved angina and quality of life at 12 months. In this prospective, multicenter, randomized controlled trial of 250 patients (mean age 63.3 years; 50.4% female) in […]
Two recent trials from China evaluated strategies to improve outcomes in patients with acute ischemic stroke treated within 4.5 hours of symptom onset. In the first open-label trial, 550 patients with large-vessel occlusion were randomized to receive either intravenous tenecteplase followed by endovascular thrombectomy or thrombectomy alone. Functional independence at […]
A Chinese prospective, randomized, parallel-group, superiority clinical trial revealed that bedtime dosing provides superior nocturnal blood pressure (BP) control and circadian rhythm improvement without compromising daytime or 24-hour BP control. The trial was conducted at 15 hospitals in China between June 2022 and April 2024 with a 12-week follow-up, compared […]
A Chinese parallel design, randomized clinical trial showed that the incidence of major cardiovascular events among patients with type 2 diabetes (T2D) was significantly lower with intensive treatment targeting a systolic blood pressure (SBP) of less than 120 mm Hg than with standard treatment targeting a SBP of less than […]
A US cohort study suggested that in the absence of evidence of end-organ damage, conservative management of inpatient high blood pressure (BP) was associated with improved outcomes compared with more intensive management. The study included 22 834 adults hospitalized for noncardiovascular diagnoses from January 1 to December 31, 2017 (mean age, […]
Patient-reported outcomes among participants who received intensive BP treatment were similar to those among participants who received standard treatment. A total of 9361 participants with hypertension at high risk for cardiovascular disease were randomly assigned to a systolic blood-pressure (SBP) target of less than 120 mm Hg or 140 mm […]