A retrospective, new-user comparative cohort study revealed that angiotensin receptor blockers (ARBs) do not differ statistically significantly in effectiveness at the class level compared with ACE (angiotensin-converting enzyme) inhibitors as first-line treatment for high blood pressure but present a better safety profile. The study included all patients with high blood […]
Both a scientific statement from the American Heart Association and an individual participant-level data meta-analysis support that pharmacological blood pressure (BP) lowering is effective for primary and secondary prevention of major cardiovascular disease (CVD), even at BP levels currently not considered for treatment. The statement provides evidence suggesting that in […]
The European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension have proposed that type of exercise can be prescribed according to initial blood pressure (BP) level to optimize lifestyle interventions for the prevention and treatment of high BP. A systematic review of meta-analyses was performed to determine […]
A US cohort study suggested that in the absence of evidence of end-organ damage, conservative management of inpatient high blood pressure (BP) was associated with improved outcomes compared with more intensive management. The study included 22 834 adults hospitalized for noncardiovascular diagnoses from January 1 to December 31, 2017 (mean age, […]
A systematic review suggested that Intensive blood pressure (BP)-lowering treatment decreases risk for orthostatic hypotension (OH). OH, before or in the setting of more intensive BP treatment, should not be viewed as a reason to avoid or de-escalate treatment for hypertension. The data were extracted from 5 trials examined BP […]
A multicenter, controlled, prospective endpoint trial confirmed that routinely taking blood pressure (BP)-lowering medications at bedtime, as opposed to upon waking, resulted in improved ambulatory BP control (significantly enhanced decrease in asleep BP and increased sleep-time relative BP decline, i.e. BP dipping) and markedly reduced major cardiovascular disease (CVD) events. […]
A Spanish multicenter, controlled, prospective endpoint trial suggested that routinely taking blood pressure (BP)-lowering medications at bedtime, as opposed to upon waking, results in improved ambulatory BP (ABP) control and decreased occurrence of major cardiovascular disease (CVD) events. A total of 19 084 hypertensive patients (60.5 ± 13.7 years of age, 8470 women) […]
A systematic review and meta-analysis suggested that global prevalence of hypertension in children is becoming more common. The analysis included 47 studies of children ages 6 to 19, from 1994 to 2018 with at least 3 separate blood pressure measurements. Standardized definitions of hypertension was based on the fourth report […]
A US retrospective cohort study concluded that both systolic and diastolic hypertension contribute significantly to cardiovascular risk. The study included 1.3 million adults in a general outpatient population. The burdens of systolic and diastolic hypertension each independently predicted adverse outcomes. In survival models, a continuous burden of systolic hypertension (≥140 […]
A secondary analysis of data from a US randomized clinical trial suggests that smokers with high blood pressure (BP) may have a higher rate of cardiovascular events associated with intensive BP control. Of 9361 participants in the trial, 466 were current smokers with systolic BP > 144 mm Hg at […]