Sex-Specific Changes of CVD Risk Factors from Childhood to Young Adulthood

A prospective UK birth cohort study demonstrate that marked changes in levels of risk factors and novel predictive biomarkers for cardiovascular diseases (CVD) occur from childhood to early adulthood. The data were from 7065 to 7626 offspring of a birth cohort study with repeat assessments of 148 molecular cardiometabolic traits […]


Statin User’s CVD Risk Tied Stronger with Inflammation Than Residual Cholesterol

A collaborative analysis of 3 multinational trials suggested that inflammatory risk was a stronger predictor of cardiovascular disease (CVD) events, CVD death, and all-cause death than residual cholesterol risk in statin users. The analysis included 31245 statin users with/or at high risk of atherosclerotic disease. The observed ranges for baseline […]


Better Cardiovascular Health Linked to Lower Cancer Risk

A French prospective cohort study concluded that better cardiovascular health (CVH) and the maintenance or improvement of CVH were associated with a lower risk of cancer. The study population included 13,933 participants (mainly Caucasian, mean age 45.3 years, 24% women). After a median follow-up of 24.8 years (19.4-24.9 years), 2,010 […]


Sleep Irregularity Linked to Subclinical Atherosclerosis

A US cross sectional and observational cohort study indicated that sleep irregularity was associated with several markers of subclinical atherosclerosis. The study included 2032 participants (mean age, 68.6±9.2 years; White 37.9%, Chinese 11.1%, Black 27.6%, Hispanic 23.4%) underwent assessments of coronary artery calcium, carotid plaque presence, carotid intima‐media thickness, and the […]


Free Sugar Intake Linked to Higher CVD Risks

A prospective UK cohort study suggested that higher free sugar intake was associated with higher cardiovascular disease (CVD) incidence and higher triglyceride concentrations within all lipoproteins. Higher fiber intake and replacement of refined grain starch and free sugars with wholegrain starch and non-free sugars, respectively, may be protective for incident […]


Thrombectomy Benefits Extended to Large Ischemic Stroke

Three trials have shown remarkable benefits of thrombectomy in patients with large ischemic strokes in countries with different medical systems. The benefits of thrombectomy were consistent across age, degree of neurologic deficit, imaging characteristics, time of treatment, and geographic location. Thrombectomy resulted in significantly better functional outcomes than medical care […]


Premature CVD Linked to Worse Midlife Brain Health

A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]


CBT Efficacy for Depression More Durable Than Pharmacotherapies

A comprehensive meta-analysis concluded that cognitive behavior therapy (CBT) is effective for depression across different formats, ages, target groups, and settings, and as effective as pharmacotherapies at the short term, but more effective at the longer term. The analysis included 409 trials (518 comparisons) with 52,702 patients. CBT had moderate […]


Antihypertensives Stimulate Type 2 and 4 Angiotensin II Receptors Linked to Lower Dementia Risk

A US cohort study suggested that initiation of medications for high blood pressure that stimulate vs inhibit type 2 and 4 angiotensin II receptors may result in a lower risk of incident dementia. The study included 57 773 patients aged 65 years or older with incident high blood pressure from January […]