SBP <130 mmHg Beneficial for Young-Older Patients

The secondary analysis of a multicenter, randomized, controlled trial in China suggested that maintaining systolic blood pressure (SBP) at <130 mmHg offers additional cardiovascular benefits among young-older patients with high blood pressure. The trial enrolled 8511 young-older (60–80 years) hypertensive patients without prior stroke to compare the intensive treatment (SBP […]


Different Genetical and Environmental Contributions in Obesity to CVD

National cohort data from Swedish twins indicate that genetically related obesity is not associated with negative health outcomes to the same extent as environmentally related obesity. A total of 17,988 twins born before 1959 were enrolled in sub-studies of the Swedish Twin Registry between 1984 and 2010 and followed on […]


Subclinical Coronary Atherosclerosis Linked to Higher MI Risk

A prospective Danish cohort study revealed that subclinical obstructive coronary atherosclerosis is associated with a more than 8-fold elevated risk for myocardial infarction (MI). The study included 9533 asymptomatic persons aged 40 years or older without known ischemic heart disease. Coronary atherosclerosis was assessed with coronary computed tomography angiography and […]


More Intensive Differential BP–Lowering Beneficial

A meta-analysis and a meta-regression of randomized clinical trials suggested that more intensive differential blood pressure (BP)–lowering may be beneficial for prevention of recurrent stroke and major cardiovascular events. The analysis included 10 randomized clinical trials comprising 40 710 patients (women 34%; mean age 65 years) with stroke or transient ischemic […]


Sex-Specific Changes of CVD Risk Factors from Childhood to Young Adulthood

A prospective UK birth cohort study demonstrate that marked changes in levels of risk factors and novel predictive biomarkers for cardiovascular diseases (CVD) occur from childhood to early adulthood. The data were from 7065 to 7626 offspring of a birth cohort study with repeat assessments of 148 molecular cardiometabolic traits […]


Statin User’s CVD Risk Tied Stronger with Inflammation Than Residual Cholesterol

A collaborative analysis of 3 multinational trials suggested that inflammatory risk was a stronger predictor of cardiovascular disease (CVD) events, CVD death, and all-cause death than residual cholesterol risk in statin users. The analysis included 31245 statin users with/or at high risk of atherosclerotic disease. The observed ranges for baseline […]