Autism Profiles Different Diagnosed Early from Later On

A study shows that autism diagnosed earlier versus later in life may reflect different developmental pathways and genetic profiles. In longitudinal data from four birth cohorts, there were two distinct socioemotional and behavioral trajectories tied to age at autism diagnosis. Genetic factors explained about 11% of the variation in when […]

Global Burden of CVDs and Risk Factors 1990-2023

Data from the Global Burden of Disease (GBD) 2023 study showed that cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, with their burden continuing to rise since 1990 due to population growth, aging, and changing exposures to harmful risk factors. The GBD study covered 204 countries […]

Digitoxin Effective in Patients with Heart Failure and Reduced Ejection Fraction

An international, double-blind, placebo-controlled trial suggested that digitoxin modestly lowered the combined risk of death from any cause or hospital admission for worsening heart failure (HF) than placebo in patients with advanced HF receiving modern therapy. The trial evaluated digitoxin in 1,240 patients with chronic HF and reduced ejection fraction […]

No Amount of Alcohol Safe for Dementia

A combined observational and genetic study indicates that all levels of alcohol consumption may raise dementia risk, and reducing alcohol use disorder (AUD) could help lower dementia incidence at the population level. The study investigated the relationship between alcohol consumption and dementia using prospective cohort, case–control, and Mendelian randomization analyses […]

Sex Differences in Heart Attacks in Younger Patients

In a US community-based study of patients aged ≤65 years between 2003 and 2018, researchers identified 1,474 index myocardial infarction (MI) events and classified them into six pathophysiologic mechanisms: atherothrombosis, spontaneous coronary artery dissection (SCAD), embolism, vasospasm, MI with nonobstructed coronary arteries of uncertain cause (MINOCA-U), and supply/demand mismatch secondary […]

Chronic Insomnia Linked to Cognitive Decline in Older Adults

A US longitudinal population-based cohort study suggests that chronic insomnia, especially with reduced sleep, is a risk factor for cognitive decline and adverse brain health in older adults. Researchers followed cognitively unimpaired participants who underwent annual neuropsychological testing and brain imaging (amyloid-PET and MRI for white matter hyperintensities [WMH]) over […]

Effects of A Ketogenic Diet, Time-Restricted Eating or Alternate-Day Fasting on Ambulatory BP

A sub-analysis of a Spanish randomized clinical trial showed that diets with varying ketogenic potential had differing impacts on blood pressure (BP). Ninety six participants with obesity (BMI >30 kg/m²) were assigned to one of five dietetic interventions: early time-restricted eating (eTRE), late time-restricted eating (lTRE), modified alternate-day fasting (mADF), […]

Low- and No-Calorie Artificial Sweeteners Intake Linked to Cognitive Decline

A Brazilian longitudinal cohort study suggested that consumption of low- and no-calorie sweeteners (LNCSs) was associated with accelerated cognitive decline. A total of 12,772 civil servants (mean age 52 years, 55% women) were followed over three study waves across eight years. Using dietary questionnaires and cognitive testing, researchers found that […]

Mediterranean Diet Promising in Lowering Dementia Risk

A US cohort study revealed genotype-dependent metabolic signatures of cognitive health and support precision nutrition approaches, such as Mediterranean diet for Alzheimer’s disease and related dementias (AD/ADRD) prevention. The study analyzed genetic, plasma metabolomic, and dietary data from 4,215 women and 1,490 men in prospective cohorts. The associations between 57 […]

Body Fat Pattern Linked to Cardiovascular Ageing

A UK cohort study suggested that both shared and sex-specific fat patterns influence cardiovascular ageing. In the study of 21,241 UK Biobank participants, machine learning was applied to 126 image-derived measures of vascular function, cardiac motion, and myocardial fibrosis to estimate cardiovascular age, with the difference from chronological age defined […]