Dose‐Response of Omega‐3 Fatty Acids for Lowering BP

A dose‐response meta‐analysis suggested that the optimal combined intake of omega‐3 fatty acids for blood pressure (BP) lowering is likely between 2 g/d and 3 g/d. Doses above 3 g/d may be associated with additional benefits in lowering BP among high risk groups for cardiovascular diseases. The analysis included 71 randomized controlled trials […]


Very High HDL-C Linked to Higher Mortality

A prospective, multicenter biobank cohort study in the UK and US revealed that very high high-density lipoprotein cholesterol (HDL-C) levels were associated with higher mortality risk in patients with coronary artery disease (CAD). There were 14 478 UK participants (from 2006; mean age 62.1 years, 76.2% men) and 5467 US participants […]


The Higher Life’s Simple 7 Scores, The Lower Dementia Risk Across Genetic Profiles

A study of incident dementia, midlife Life’s Simple 7 (LS7) scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer’s Disease showed that across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia in a US cohort. The study included 8,823 European […]


Prevalence and Clinical Significance of DNA Variants Predisposing to Cardiomyopathy

A genetic association study indicates that 0.7% of participants harbor a pathogenic variant related to inherited cardiomyopathy and are at increased risk of cardiovascular disease (CVD) and all-cause mortality. The study included 9667 US participants (mean age 54.0 years; 43.8% women; 27.5% African and 72.5% European ancestry) and 49 744 UK […]


Antidepressants’ Effect on Health-Related Quality of Life Over Time Questioned

An observational comparative cohort study with secondary database analysis suggested that the real-world effect of using antidepressants did not continue to improve patients’ health-related quality of life (HRQoL) over time. The study was using data from a US nationally representative database. HRQoL was measured using the SF-12 health survey and […]


Achieving T2D Treatment Goals May Extend Life Expectancy

A US decision analytical model suggested that achieving recommended goals of glycated hemoglobin (HbA1c), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and body mass index (BMI) may extend the life expectancy (LE) of people with type 2 diabetes (T2D). The model was calibrated to a nationally representative sample of […]


Healthy Lifestyle Linked to Longer Life without Dementia

A US prospective cohort study showed that a healthy lifestyle was associated with a longer life expectancy, and a larger proportion of their remaining years without Alzheimer’s dementia (AD). The study included 2449 participants aged 65 years and older (mean 76 years, 63% women, African American>50%) from 1993 to 2009, […]