The Higher Life’s Simple 7 Scores, The Lower Dementia Risk Across Genetic Profiles

A study of incident dementia, midlife Life’s Simple 7 (LS7) scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer’s Disease showed that across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia in a US cohort. The study included 8,823 European […]

Prevalence and Clinical Significance of DNA Variants Predisposing to Cardiomyopathy

A genetic association study indicates that 0.7% of participants harbor a pathogenic variant related to inherited cardiomyopathy and are at increased risk of cardiovascular disease (CVD) and all-cause mortality. The study included 9667 US participants (mean age 54.0 years; 43.8% women; 27.5% African and 72.5% European ancestry) and 49 744 UK […]

Antidepressants’ Effect on Health-Related Quality of Life Over Time Questioned

An observational comparative cohort study with secondary database analysis suggested that the real-world effect of using antidepressants did not continue to improve patients’ health-related quality of life (HRQoL) over time. The study was using data from a US nationally representative database. HRQoL was measured using the SF-12 health survey and […]

Achieving T2D Treatment Goals May Extend Life Expectancy

A US decision analytical model suggested that achieving recommended goals of glycated hemoglobin (HbA1c), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and body mass index (BMI) may extend the life expectancy (LE) of people with type 2 diabetes (T2D). The model was calibrated to a nationally representative sample of […]

Healthy Lifestyle Linked to Longer Life without Dementia

A US prospective cohort study showed that a healthy lifestyle was associated with a longer life expectancy, and a larger proportion of their remaining years without Alzheimer’s dementia (AD). The study included 2449 participants aged 65 years and older (mean 76 years, 63% women, African American>50%) from 1993 to 2009, […]

SGLT2 Inhibitor’s Heart Benefit Extended

A systematic review and meta-analysis concluded that sodium–glucose cotransporter-2 (SGLT2) inhibitors reduced hospitalizations for heart failure (HF) regardless of the presence of diabetes. The analysis included trials that randomly assigned adults with HF to SGLT2 inhibitors or control. Time-to-event individual patient data were reconstructed from published Kaplan–Meier plots; time-varying risk […]

Treatment for Mild Chronic Hypertension during Pregnancy Beneficial

A US open-label, multicenter, randomized trial concluded that in pregnant women with mild chronic high blood pressure (BP), a strategy of targeting BP<140/90 mm Hg was associated with better pregnancy outcomes than a strategy of reserving treatment only for severe high BP, with no increase in the risk of small-for-gestational-age […]

Sleep Loss Predisposes to Abdominal Visceral Obesity

A US randomized, controlled, crossover study in healthy, nonobese individuals revealed that sleep restriction combined with ad libitum food promotes excess energy intake, weight gain and particularly central accumulation of fat without changing energy expenditure. The study included 12 healthy, nonobese individuals (9 males, age range 19 to 39 years), […]

Daytime Napping and Dementia May Drive Each Other

A US prospective, observational cohort study suggested that excessive daytime napping and dementia may possess a bidirectional relationship or share common pathophysiological mechanisms. The study examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer’s dementia (AD) in 1401 participants (mean age 81.4 […]