Mediterranean Diet as First-Option for Irritable Bowel Syndrome

Findings of a UK clinical trial support the use of the Mediterranean diet (MD) as a first-line therapy for irritable bowel syndrome (IBS). A total of 139 adults with IBS (mean age 40.4 years; 80% women) from across the UK were randomized to follow either the MD (n = 68) […]

Early Life Sugar Restriction Linked to CVD Benefits Later Life

A natural experiment study investigated whether exposure to sugar rationing during early life was associated with reduced risk of cardiovascular disease (CVD) in adulthood. Using data from 63,433 UK Biobank participants born between 1951 and 1956, researchers compared individuals exposed to sugar rationing in utero or early childhood with those […]

Efficacy and Safety of Different Exercises for Knee Osteoarthritis

A systematic review and network meta-analysis evaluated the efficacy and safety of different exercise modalities for managing knee osteoarthritis, including aerobic, flexibility, mind-body, neuromotor, strengthening, and mixed exercises. A total of 217 randomized controlled trials involving 15,684 participants were analyzed, with outcomes assessed at short-term (4 weeks), mid-term (12 weeks), […]

British Dietary Guidelines for Chronic Constipation

The British Dietetic Association has developed the first comprehensive evidence-based dietary guidelines for the management of chronic constipation in adults. Four systematic reviews and meta-analyses encompassing 75 randomized controlled trials informed 59 recommendation statements, developed through the GRADE framework and Delphi consensus among a multidisciplinary Guideline Steering Committee. The recommendations […]

AACE 2025 Updated Algorithm for Management of Dyslipidemia

The American Association of Clinical Endocrinology (AACE) has released its 2025 Consensus Statement and updated algorithm for the management of adults with dyslipidemia, offering concise visual guidance and tables to support clinical decision-making aimed at reducing atherosclerotic cardiovascular disease (ASCVD) and triglyceride-induced pancreatitis risk. Developed by an international multidisciplinary task […]

Autism Profiles Different Diagnosed Early from Later On

A study shows that autism diagnosed earlier versus later in life may reflect different developmental pathways and genetic profiles. In longitudinal data from four birth cohorts, there were two distinct socioemotional and behavioral trajectories tied to age at autism diagnosis. Genetic factors explained about 11% of the variation in when […]

Global Burden of CVDs and Risk Factors 1990-2023

Data from the Global Burden of Disease (GBD) 2023 study showed that cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, with their burden continuing to rise since 1990 due to population growth, aging, and changing exposures to harmful risk factors. The GBD study covered 204 countries […]

Digitoxin Effective in Patients with Heart Failure and Reduced Ejection Fraction

An international, double-blind, placebo-controlled trial suggested that digitoxin modestly lowered the combined risk of death from any cause or hospital admission for worsening heart failure (HF) than placebo in patients with advanced HF receiving modern therapy. The trial evaluated digitoxin in 1,240 patients with chronic HF and reduced ejection fraction […]

No Amount of Alcohol Safe for Dementia

A combined observational and genetic study indicates that all levels of alcohol consumption may raise dementia risk, and reducing alcohol use disorder (AUD) could help lower dementia incidence at the population level. The study investigated the relationship between alcohol consumption and dementia using prospective cohort, case–control, and Mendelian randomization analyses […]

Sex Differences in Heart Attacks in Younger Patients

In a US community-based study of patients aged ≤65 years between 2003 and 2018, researchers identified 1,474 index myocardial infarction (MI) events and classified them into six pathophysiologic mechanisms: atherothrombosis, spontaneous coronary artery dissection (SCAD), embolism, vasospasm, MI with nonobstructed coronary arteries of uncertain cause (MINOCA-U), and supply/demand mismatch secondary […]