Bedtime Dosing Bettered Morning Dosing in High BP

A Chinese prospective, randomized, parallel-group, superiority clinical trial revealed that bedtime dosing provides superior nocturnal blood pressure (BP) control and circadian rhythm improvement without compromising daytime or 24-hour BP control. The trial was conducted at 15 hospitals in China between June 2022 and April 2024 with a 12-week follow-up, compared […]

Antidepressant Discontinuation Symptoms Not Clinically Significant

A systematic review and meta-analysis indicate that while antidepressant discontinuation is associated with a mild increase in physical symptoms, the average symptom burden does not reach the threshold for clinically significant discontinuation syndrome. Researchers examined symptoms using standardized measures such as the Discontinuation-Emergent Signs and Symptoms (DESS) scale and tracked […]

Age on the Association of Risk Factors and Stroke

An international case–control study suggested that vascular risk factors influence stroke risk differently across age groups. The study enrolled age- and sex-matched cases of the first acute stroke and controls across 32 countries between Jan 11, 2007, and Aug 8, 2015. Participants underwent clinical assessments and provided blood and urine […]

Early Intensive BP-Lowering Beneficial in Intracerebral Hemorrhage

An individual patient-data pooled analysis of the four Intensive Blood Pressure (BP) Reduction in Acute Cerebral Haemorrhage Trials (INTERACT) supports the safety and efficacy of early intensive BP-lowering in intracerebral hemorrhage. There were 404 patients in INTERACT1, 2829 in INTERACT2, 7036 in INTERACT3, and 1043 in INTERACT4, respectively. INTERACT1–3 enrolled […]

Early DOACs Post Ischemic Stroke and Atrial Fibrillation Beneficial

A systematic review and prospective individual participant data meta-analysis of randomized controlled trials supports early direct oral anticoagulants (DOACs) initiation within 4 days for patients with acute ischemic stroke and atrial fibrillation to reduce the risk of recurrent stroke without increasing bleeding risk. The analysis included four trials met inclusion […]

Salt in Water Linked to High BP and Albuminuria

A Kenya panel study suggested that drinking water sodium-chloride may elevate blood pressure (BP) and kidney disease risk, even in populations with minimal traditional chronic disease risk factors. The two-year panel study was conducted in 2022 and 2023 among 327 Daasanach adults over 18 years old in northern Kenya (434 […]

Late Endovascular Thrombectomy Effective in Vertebrobasilar Artery Occlusion

A multicenter, prospective Chinese cohort study suggested that endovascular thrombectomy (EVT) plus best medical treatment (BMT) improved functional outcomes and survival in patients with vertebrobasilar artery occlusion treated beyond 24 hours after last known well time. Conducted between 2019 and 2024 across 11 comprehensive stroke centers in China, the study […]

Morning Naps Linked to Dementia Risk

A US clinical-pathologic cohort study found that more frequent morning naps were linked to a higher risk of developing Alzheimer’s dementia. Additionally, more naps in the early afternoon and more consistent nap patterns were linked to lower levels of Alzheimer’s pathology. The study analyzed data from 936 older adults (aged […]

Healthy Lifestyle’s Benefits Go beyond Weight Loss

A pooled analysis of lifestyle intervention trials suggested that adopting a healthy lifestyle can confer metabolic benefits beyond weight loss (WL) alone. The study investigated how individual responses to long-term lifestyle interventions for WL affect cardiometabolic risk by pooling data from three long-term lifestyle WL-intervention trials with adherence rates of […]

Low Sodium DASH Diet Reduced BP

A US randomized, 4-period crossover feeding study revealed that sodium reduction, especially when combined with a Dietary Approaches to Stop Hypertension (DASH)-style diet optimized for diabetes (DASH4D), can significantly lower blood pressure (BP) in patients with type 2 diabetes (T2D) and high BP, even among those already using multiple antihypertensive […]