A Chinese cohort study suggested a causal effect of gut microbiota on non-HDL-c and identified 3-indolepropionic acid and N-methyltryptamine as key effectors of gut microbiota to the variation of non-high-density lipoprotein cholesterol (non-HDL-c). The study included a total of 1361 community-dwelling participants without major diseases and free of antibiotics and lipid-lowering […]
A US prospective population based cohort study suggested that higher ultra-processed food intake was associated with slightly increased all-cause mortality. The associations were mainly driven by meat/poultry/seafood based ready-to-eat products, sugar and artificially sweetened beverages, dairy based desserts, and ultra-processed breakfast foods. The study included 74 563 women (1984-2018) and 39 501 […]
The US guideline for the management of hypertrophic cardiomyopathy (HCM) have been updated. The top 10 take-home messages are: Shared decision-making is essential to provide the best clinical care. Referral to multidisciplinary HCM centers with appropriate expertise can be important to optimizing care for patients with HCM. Careful ascertainment of […]
A single-stage common-variant genome-wide association study (GWAS) of blood pressure (BP) in European-ancestry adults improved BP polygenic risk scores (PRS) and provided additional insights into the genetic contribution of BP. The study identified 113 novel loci, reporting a total of 2,103 independent genetic signals in 1,028,980 European individuals from the […]
The US Women’s Health Initiative (WHI) clinical trial results do not support hormone therapy with oral conjugated equine estrogens plus medroxyprogesterone acetate for postmenopausal women or conjugated equine estrogens alone for those with prior hysterectomy to prevent cardiovascular disease, dementia, or other chronic diseases. However, hormone therapy is effective for […]