A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]
A comprehensive meta-analysis concluded that cognitive behavior therapy (CBT) is effective for depression across different formats, ages, target groups, and settings, and as effective as pharmacotherapies at the short term, but more effective at the longer term. The analysis included 409 trials (518 comparisons) with 52,702 patients. CBT had moderate […]
A US cohort study suggested that initiation of medications for high blood pressure that stimulate vs inhibit type 2 and 4 angiotensin II receptors may result in a lower risk of incident dementia. The study included 57 773 patients aged 65 years or older with incident high blood pressure from January […]
A prospective US cohort study with up to 36 years of follow-up concluded that greater adherence to several healthy eating patterns was associated with a lower risk of total and cause-specific mortality. The study included 75 230 women (1984-2020, mean baseline age, 50.2 years) and 44 085 men (1986-2020, mean […]
A UK longitudinal cohort study suggested that the predictive ability of a polygenic risk score (PRS) for coronary artery disease (CAD) was greater in younger individuals and could be used to better identify patients with borderline and intermediate clinical risk who should initiate statin therapy. Polygenic risk for CAD was […]