An individual participant data meta-analysis concluded that most (>90%) of all reports of muscle symptoms with statin therapy were not due to the statin, although statins did cause a small proportional increase in reports of muscle pain, largely during the first year of treatment. The analysis included 19 double-blind trials […]
A prospective UK cohort study suggested that high levels of cognitively passive sedentary behaviors (SB) were associated with increased risk of dementia, while cognitively active SB were associated with reduced risk of dementia. The study included 146,651 participants who were 60 years or older (mean age 64.59 years) and did […]
A multicenter, open-label, blinded–end point, randomized clinical trial in China showed that remote ischemic conditioning (RIC) was associated with better neurologic function in patients with acute moderate ischemic stroke. The trial randomly assigned 1893 patients (mean age, 65 years; women 34.1%; 93.8% completed the trial) within 48 hours after symptom […]
A meta-analyses and metaregressions concluded that the beneficial effects of salt substitutes on blood pressure and clinical outcomes were consistent and might be generalizable across diverse population subgroups worldwide. The study included 21 trials and 31 949 participants, with 19 reporting effects on blood pressure and 5 reporting effects on […]
A drug-target Mendelian randomization (MR) analysis indicated adverse neurocognitive effects related to statins but not proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition. Data were from a combined sample of ∼740,000 participants in predominantly European ancestry-based genome-wide association cohort studies. There was a neutral cognitive profile related to genetic PCSK9 inhibition, […]
A US randomized clinical trial suggested that early time-restricted eating (eTRE) was more effective for weight loss than eating over a window of 12 or more hours. A total of 90 obese participants (mean body mass index, 39.6; age, 43 years; 80% female) received weight-loss treatment (energy restriction [ER] of […]
Data from a validated and complete registration of all 2,494 acute myocardial infarction (MI) cases in Augsburg, Germany, during warm seasons (May to September) from 2001 to 2014, suggested that heat-related non-fatal MI risk was elevated among users of anti-platelet medication and beta-receptor blockers, respectively, but not among non-users, with […]