A US prospective, observational cohort study suggested that excessive daytime napping and dementia may possess a bidirectional relationship or share common pathophysiological mechanisms. The study examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer’s dementia (AD) in 1401 participants (mean age 81.4 […]
A systematic review and meta-analysis suggests that the absolute benefits of statins are modest and may not be strongly mediated through the degree of low-density lipoprotein cholesterol (LDL-C) reduction. The analysis included 21 randomized clinical trials that examined the effectiveness of statins in reducing total mortality and cardiovascular outcomes with […]
A substudy of the randomized clinical trial compared intensive vs standard systolic blood pressure (SBP) control revealed that the intensive BP treatment was associated with increased, rather than decreased, cerebral perfusion. The substudy included 547 participants (mean age 67.5 years, 40.0% women) with whole-brain cerebral blood flow (CBF) measured at […]
An UK randomized trial revealed that traditional dietary advice (TDA), low FODMAP diet (LFD) and gluten-free diet (GFD) are all effective approaches in non-constipated irritable bowel syndrome (IBS), but TDA is the most patient-friendly in terms of cost and convenience. A total of 99 patients with non-constipated IBS completed the […]