A series of randomized, placebo-controlled n-of-1 trials (a randomized trial in individual patients) found no overall effect of atorvastatin 20 mg on muscle symptoms compared with placebo in participants who had previously reported severe muscle symptoms when taking statins. A total of 200 participants who had recently stopped or were […]
A global study concluded that a diet with a high glycemic index was associated with an increased risk of cardiovascular disease (CVD) and death. The study included 137,851 participants between the ages of 35 and 70 years living on five continents, with a median follow-up of 9.5 years. Country-specific food-frequency […]
A multi-parametric cardiovascular magnetic resonance (CMR) assessment revealed myocardial injury in approximately half of hospitalized COVID-19 patients. A total of 148 hospitalized COVID-19 patients (64 ± 12 years, 70% male, 32% requiring ventilatory support) and troponin elevation discharged from six hospitals in the UK underwent convalescent CMR (including adenosine stress perfusion if indicated) […]
Analyses of community-based cohort studies suggested increasing cardiovascular disease (CVD) risk beginning at lower thresholds of systolic blood pressure (SBP) for women than for men. The study included 27 542 participants (54% women) without baseline CVD who had standardized SBP measurements performed in 1 of 4 community-based cohort studies. Over 28±12 […]
A Mendelian randomization (MR) study provided the evidence that the relationship between blood pressure (BP) and risk of atrial fibrillation (AF) might be causal. Genetic variants associated with the BP traits were retrieved from 299 024 subjects of European ancestry. Two-sample MR analyses were used to examine the potential causal association […]
A study shows that human sleep is synchronized with lunar phases regardless of ethnic and sociocultural background, and of the level of urbanization. The study uses wrist actimetry to show a clear synchronization of nocturnal sleep timing with the lunar cycle in participants living in environments that range from a […]