An exome sequencing study of autism spectrum disorder (ASD) identified 102 risk genes at a false discovery rate of 0.1 or less. The study included 35,584 total samples, 11,986 with ASD, and used an enhanced analytical framework to integrate de novo and case-control rare variation. 49 of the risk genes […]
An international multicenter case-control cohort study suggested that high density 1K plaque (the volume of plaque with more than 1000 Hounsfield unit) detected by coronary computed tomography angiography (CCTA) is associated with lower risk of future occurrence of acute coronary syndrome (ACS). The study included 189 patients who experienced vs […]
A US prospective cohort study suggested that unhealthy low-carbohydrate-diet and low-fat-diet scores were associated with higher total mortality, whereas healthy low-carbohydrate-diet and low-fat-diet scores were associated with lower total mortality. The study included 37 233 adults 20 years or older (mean age 49.7; 52.6% female) with 24-hour dietary recall data […]
Sex-specific analyses of longitudinal BP measures in US cohort studies indicate that blood pressure (BP) measures progress more rapidly in women than in men, beginning early in life. The analyses included 32 833 participants (54% female) spanning ages 5 to 98 years from 1971 to 2014 in 4 community-based US cohort […]