Two prospective cohort studies revealed that physical activity was associated with a lower risk of mortality both in the general population and in patients with stable coronary heart disease worldwide. The 1st study included 130 843 participants without pre-existing cardiovascular disease, and followed 6·9 years. Higher physical activity was associated with […]
An analysis of individual level pooled data from 10 prospective cohort studies concluded that obesity is associated with earlier onset of heart failure (HF), increased risk of HF; and greater proportion of life lived with HF in the context of shorter total longevity. A total of 170,205 adults free from […]
Findings from a prospective cohort study challenge current global dietary guidelines. A total of 135 335 individuals aged 35 to 70 years without cardiovascular disease (CVD) were enrolled between Jan 1, 2003, and March 31, 2013 from 613 communities in 18 low-income, middle-income, and high-income countries in seven geographical regions globally. […]
A randomized, double-blind trial of canakinumab targeting interleukin-1β innate immunity pathway revealed a significantly lower rate of recurrent cardiovascular events in patients of myocardial infarction (MI). The trial included 10,061 patients with previous MI and a high-sensitivity C-reactive protein （hsCRP） level of 2 mg or more per liter. Canakinumab (at […]
Patient-reported outcomes among participants who received intensive BP treatment were similar to those among participants who received standard treatment. A total of 9361 participants with hypertension at high risk for cardiovascular disease were randomly assigned to a systolic blood-pressure (SBP) target of less than 120 mm Hg or 140 mm […]
A prospective cohort study of a general Japanese population demonstrated a significant independent association between increased day-to-day blood pressure variability (BPV) measured with home blood pressure monitoring and risk of dementia. The study included 1674 community-dwelling Japanese elderly without dementia, ≥60 years of age, and followed up for 5 years […]
A study revealed that estimated sodium intake (ESI) >3.7 g/day is associated with adverse cardiac remodeling and function. The study performed speckle-tracking analysis on echocardiograms with available urinary sodium data (N = 2,996). Mean age of participants was 49 ± 14 years, 57% were female, 50% were African American, and […]
A mendelian randomization study concluded that a genetic predisposition to higher serum calcium levels was associated with increased risk of coronary artery disease (CAD) and myocardial infarction (MI). The study included 60 801 CAD cases (approximately 70% with MI) and 123 504 noncases, with baseline data collected from 1948 and populations derived […]
A US study showed that improved diet quality over 12 years was consistently associated with a decreased risk of death. The study used Cox proportional-hazards models to calculate adjusted hazard ratios for total and cause-specific mortality among 47,994 women and 25,745 men from 1998 through 2010, with changes in diet […]
http://jamanetwork.com/The cross-sectional baseline data from a population-based cohort study in UK identified associations between body mass index (BMI) and risk of hypertension, coronary heart disease, type 2 diabetes, and elevated systolic and diastolic blood pressures. The study included 119 859 participants with complete phenotypic (medical and sociodemographic) and genetic data between […]