According to a systematic review and meta-analysis encompassing over 22 million participants and spanning from 1966 to 2021, specific mental disorders have been confirmed to be significantly associated with an increased risk of Acute Coronary Syndrome (ACS). The study screened 3,616 initial records from three major databases, ultimately incorporating 25 high-quality articles that met the criteria for quantitative synthesis. The results indicate that, after adjusting for traditional cardiovascular risk factors, patients with depressive disorder (Hazard Ratio [HR] 1.40), anxiety disorder (HR 1.63), sleep disorder (HR 1.60), and posttraumatic stress disorder (PTSD; HR 2.73) had a significantly elevated risk of developing ACS, with PTSD showing the strongest association and a moderate certainty of evidence. However, bipolar disorder and psychotic disorders, while showing similar risk trends, did not reach statistical significance in this analysis. These findings underscore the importance of integrating mental health assessment and intervention into the overall strategy for cardiovascular disease prevention and management, highlighting the need for future research to further elucidate the underlying bio-behavioral mechanisms. Source: https://jamanetwork.com/journals/jamapsychiatry/
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