Cardiovascular Diseases

Brain’s Stress-Related Activity Mediated CVD Benefit of Physical Activity

A US cohort study suggested that physical activity (PA) appears to reduce cardiovascular disease (CVD) risk in part by acting through the brain’s stress-related activity. The study included a total of 50,359 adults (median age 60 years; 40.1% male). Stress-related neural activity was measured as the ratio of resting amygdalar-to-cortical activity (AmygAC) in a subset of participants. Greater PA was associated with both lower AmygAC (standardized β: −0.245; P = 0.016) and CVD events (HR: 0.802; P < 0.001) in multivariable models. AmygAC reductions partially mediated PA’s CVD benefit (OR: 0.96; P < 0.05). Moreover, PA’s benefit on incident CVD events was greater among those with (vs without) preexisting depression (HR: 0.860; vs HR: 0.929; P interaction = 0.011). Additionally, PA above guideline recommendations further reduced CVD events, but only among those with preexisting depression (P interaction = 0.023). The study provided one of the mechanisms underlying the psychological and CVD benefits of PA and may explain the novel observation that PA reduces CVD risk to a greater extent among individuals with depression. Source: https://www.jacc.org/

hyangiu

Recent Posts

Dose Response of Physical Activity in CVD and Mortality

Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular…

20 hours ago

Faster Walking Pace May Reduce Risk of Cardiac Arrhythmias

A prospective UK cohort study found that both self-reported average or brisk walking pace and…

1 day ago

4:3 Intermittent Fasting Outperforms Daily Caloric Restriction for Weight Loss

A U.S. randomized clinical trial found that 4:3 intermittent fasting (IMF) led to slightly greater…

4 weeks ago

Comparative CVD Efficacy of Newer Glucose-Lowering Drugs in Elderly T2D Patients

A Danish nationwide cohort study provided real world evidence that both glucagon-like peptide 1 receptor…

4 weeks ago

Efficacy of Non-Surgical and Non-Interventional Treatments in Low Back Pain

A systematic review and meta-analysis of placebo-controlled randomized trials showed that there is moderate certainty…

1 month ago

Statin Use Linked to Lower Risks of HCC and Liver Disease Progression

A US cohort study indicated that statin use may reduce the risks of hepatocellular carcinoma…

1 month ago

This website uses cookies.