A longitudinal cohort and mendelian randomization study suggested there was a modest, but significant longitudinal and causal relationship between neuroticism and atrial fibrillation (AF). In 394,834 UK participants (mean age 56.3 years, 45.9% male), AF occurred in 23,509 (6.0%) during a 10-year follow-up. Based on the median summary score from a self-questionnaire of 12 neurotic behavior domains, the risk of incident AF significantly increased in the high neuroticism score group (score ≥4, inverse probability of treatment weighting–adjusted HR: 1.05) compared with the low neuroticism group. In the subgroup analysis, younger age, lower body mass index, or nonsmoker/ex-smoker participants were particularly susceptible to increased AF risk due to high neuroticism scores. A Mendelian randomization analysis of the UK and another European genome-wide association studies confirmed a significant causal relationship between an increase in neuroticism score and increased risk of AF (OR by inverse variance–weighted method 1.06) without evidence of reverse causality. Individuals with high neuroticism who are more susceptible to depressive symptoms have also shown higher risk for developing heart failure and myocardial infarction in a recent study. The findings suggest that mental health screening and management of risk factors may be beneficial. Source: https://www.jacc.org/

hyangiu

Recent Posts

Dose Response of Physical Activity in CVD and Mortality

Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular…

20 hours ago

Faster Walking Pace May Reduce Risk of Cardiac Arrhythmias

A prospective UK cohort study found that both self-reported average or brisk walking pace and…

1 day ago

4:3 Intermittent Fasting Outperforms Daily Caloric Restriction for Weight Loss

A U.S. randomized clinical trial found that 4:3 intermittent fasting (IMF) led to slightly greater…

4 weeks ago

Comparative CVD Efficacy of Newer Glucose-Lowering Drugs in Elderly T2D Patients

A Danish nationwide cohort study provided real world evidence that both glucagon-like peptide 1 receptor…

4 weeks ago

Efficacy of Non-Surgical and Non-Interventional Treatments in Low Back Pain

A systematic review and meta-analysis of placebo-controlled randomized trials showed that there is moderate certainty…

1 month ago

Statin Use Linked to Lower Risks of HCC and Liver Disease Progression

A US cohort study indicated that statin use may reduce the risks of hepatocellular carcinoma…

1 month ago

This website uses cookies.