A Novel Circulating MicroRNA for Myocarditis Diagnosis

A novel microRNA has been identified in mice and humans with myocarditis, and that the human homologue could be used to distinguish patients with myocarditis from those with myocardial infarction. The human homologue, designated hsa-miR-Chr8:96, was identified in four independent cohorts of patients with myocarditis. The area under the receiver-operating-characteristic curve for this novel microRNA for distinguishing patients with acute myocarditis from those with myocardial infarction was 0.927. The microRNA retained its diagnostic value in models after adjustment for age, sex, ejection fraction, and serum troponin level. The diagnosis of acute myocarditis typically requires either endomyocardial biopsy or cardiovascular magnetic resonance imaging. Source: https://www.nejm.org/