An UK prospective population based cohort study found that genetic and lifestyle factors were independently associated with risk of incident stroke. The study recruited 306 473 men and women, aged 40-73 years, between 2006 and 2010. During a median follow-up of 7.1 years (2 138 443 person years), 2077 incident strokes (1541 ischemic stroke, 287 intracerebral hemorrhage, and 249 subarachnoid hemorrhage) were ascertained. The risk of incident stroke was 35% higher among those at top third of polygenic score compared with those at bottom third. Unfavorable lifestyle (0 or 1 healthy lifestyle factors) was associated with a 66% increased risk of stroke compared with a favorable lifestyle (3 or 4 healthy lifestyle factors). The association with lifestyle was independent of genetic risk stratums. A healthy lifestyle was determined on the basis of four factors: non-smoker, healthy diet, body mass index https://www.bmj.com/
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