An UK prospective population based cohort study found that genetic and lifestyle factors were independently associated with risk of incident stroke. The study recruited 306 473 men and women, aged 40-73 years, between 2006 and 2010. During a median follow-up of 7.1 years (2 138 443 person years), 2077 incident strokes (1541 ischemic stroke, 287 intracerebral hemorrhage, and 249 subarachnoid hemorrhage) were ascertained. The risk of incident stroke was 35% higher among those at top third of polygenic score compared with those at bottom third. Unfavorable lifestyle (0 or 1 healthy lifestyle factors) was associated with a 66% increased risk of stroke compared with a favorable lifestyle (3 or 4 healthy lifestyle factors). The association with lifestyle was independent of genetic risk stratums. A healthy lifestyle was determined on the basis of four factors: non-smoker, healthy diet, body mass index <30 kg/m2, and regular physical exercise. The findings are consistent with previous studies that genetic and lifestyle factors were independently associated with susceptibility to coronary artery disease (CAD), and highlight the potential of lifestyle interventions to reduce risks of CAD and stroke across entire populations, even in those at high genetic risk. Source: https://www.bmj.com/

hyangiu

Recent Posts

4:3 Intermittent Fasting Outperforms Daily Caloric Restriction for Weight Loss

A U.S. randomized clinical trial found that 4:3 intermittent fasting (IMF) led to slightly greater…

2 days ago

Comparative CVD Efficacy of Newer Glucose-Lowering Drugs in Elderly T2D Patients

A Danish nationwide cohort study provided real world evidence that both glucagon-like peptide 1 receptor…

1 week ago

Efficacy of Non-Surgical and Non-Interventional Treatments in Low Back Pain

A systematic review and meta-analysis of placebo-controlled randomized trials showed that there is moderate certainty…

2 weeks ago

Statin Use Linked to Lower Risks of HCC and Liver Disease Progression

A US cohort study indicated that statin use may reduce the risks of hepatocellular carcinoma…

2 weeks ago

Clinical Significance of Carotid Artery Plaque with Age and Sex

A US cohort study suggests that carotid artery plaque (CAP) becomes very common with increasing…

3 weeks ago

Substituting Butter with Plant-Based Oils May Improve Survival

A prospective US population-based cohort study suggested that higher intake of butter was associated with…

4 weeks ago

This website uses cookies.