A longitudinal study in the US revealed that low-density lipoprotein cholesterol (LDL-C) and non–high-density lipoprotein cholesterol (HDL-C) ≥160 mg/dL were independently associated with a 50% to 80% increased relative risk of cardiovascular disease (CVD) mortality in a low risk cohort with long-term follow-up. The study included 36 375 participants (72% men, median age 42) without a history of CVD or diabetes mellitus and defined as low risk (<7.5%) for 10-year atherosclerotic CVD events at baseline, with a median follow-up of 26.8 years. There were 1086 CVD and 598 coronary heart disease deaths. Compared with LDL-C https://www.ahajournals.org/
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