An open-label, cluster-randomized trial in the UK showed that intensive weight management achieved remission of type 2 diabetes (T2D). The trial included 306 patients from 49 general practices between July 25, 2014, and Aug 5, 2017. The patients aged 20–65 years who had been diagnosed with T2D within the past 6 years, had a body-mass index of 27–45 kg/m2, and were not receiving insulin. The intervention comprised withdrawal of antidiabetic and antihypertensive drugs, total diet replacement (825–853 kcal/day formula diet consisting of 59% carbohydrates, 13% fat, 26% protein, and 2% fiber for 3–5 months), stepped food reintroduction (comprising of 50% carbs, 35% total fat, and 15% protein for 2–8 weeks), and structured support for long-term weight loss maintenance. Remission of diabetes was defined as glycated hemoglobin of less than 6·5% (http://www.thelancet.com/
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