BMI Linked to Cardiometabolic Diseases

http://jamanetwork.com/The cross-sectional baseline data from a population-based cohort study in UK identified associations between body mass index (BMI) and risk of hypertension, coronary heart disease, type 2 diabetes, and elevated systolic and diastolic blood pressures. The study included 119 859 participants with complete phenotypic (medical and sociodemographic) and genetic data between 2006 and 2010, 47.4% were men; mean age was 56.87 years. A polygenic risk score comprising 93 single-nucleotide polymorphisms associated with BMI from previous genome-wide association studies was constructed, and applied to derive causal estimates using a mendelian randomization approach. Mendelian randomization analysis showed significant positive associations between genetically instrumented higher BMI and risk of hypertension (odds ratio [OR] per 1-SD higher BMI, 1.64), coronary heart disease (OR, 1.35) and type 2 diabetes (OR, 2.53), as well as systolic blood pressure (β = 1.65 mm Hg) and diastolic blood pressure (β = 1.37 mm Hg). These associations were independent of age, sex, Townsend deprivation scores, alcohol intake, and smoking history. BMI represents an important modifiable factor for ameliorating the risk of cardiometabolic disease in the general population. Source: http://jamanetwork.com/

hyangiu

Recent Posts

Dose Response of Physical Activity in CVD and Mortality

Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular…

1 day ago

Faster Walking Pace May Reduce Risk of Cardiac Arrhythmias

A prospective UK cohort study found that both self-reported average or brisk walking pace and…

2 days ago

4:3 Intermittent Fasting Outperforms Daily Caloric Restriction for Weight Loss

A U.S. randomized clinical trial found that 4:3 intermittent fasting (IMF) led to slightly greater…

4 weeks ago

Comparative CVD Efficacy of Newer Glucose-Lowering Drugs in Elderly T2D Patients

A Danish nationwide cohort study provided real world evidence that both glucagon-like peptide 1 receptor…

1 month ago

Efficacy of Non-Surgical and Non-Interventional Treatments in Low Back Pain

A systematic review and meta-analysis of placebo-controlled randomized trials showed that there is moderate certainty…

1 month ago

Statin Use Linked to Lower Risks of HCC and Liver Disease Progression

A US cohort study indicated that statin use may reduce the risks of hepatocellular carcinoma…

1 month ago

This website uses cookies.