Vaccines Work Against Hand, Foot, and Mouth Disease疫苗有效预防手足口病

Two vaccines developed in China show efficacy against enterovirus 71 (EV71), the major cause of hand, foot, and mouth disease or herpangina. Two randomized, double-blind, placebo-controlled trials involved 10,007 (healthy children 6 to 35 months of age) and 12000 (healthy children 6 to 71 months of age), respectively, showed 94.8% to 97.4% efficacy according to the intention-to-treat analysis. The safety profile was comparable to placebo in one trial and having fever more common in the vaccine group in another trial. 中国开发的两种疫苗显示对肠道病毒71型（EV71）有效，该病毒为手，足，口病的主要病因。两项随机，双盲，安慰剂对照试验分别包括10,007名（月龄6〜35）和12000名（月龄6〜71）健康儿童，根据意向性治疗分析结果显示有效率高达94.8％至97.4％。其中一项试验疫苗的安全性与安慰剂相似，而另一项试验中发热在疫苗组更常见。