Flu Vaccine Effective and Safe in Pregnant Women流感疫苗对孕妇安全有效

Two double-blind, randomized, placebo-controlled trials of trivalent inactivated influenza vaccine (IIV3) in South Africa showed that influenza vaccine was immunogenic in HIV-uninfected and HIV-infected pregnant women and provided partial protection against confirmed influenza in both groups of women and in infants who were not exposed to HIV. The study cohorts included 2116 pregnant women who were not infected with HIV and 194 pregnant women who were infected with HIV. The immunogenicity, safety, and efficacy of IIV3 in pregnant women and their infants were evaluated until 24 weeks after birth. There was no significant adverse effect. Source: http://www.nejm.org/南非的两个双盲，随机，安慰剂对照的三元灭活流感疫苗（IIV3）试验表明，流感疫苗在艾滋病毒感染和未感染的孕妇中均可致免疫反应，并在该两组妇女和未暴露于艾滋病毒的婴儿中防止了部分流感的发生。该研究包括了2116名未感染艾滋病毒的孕妇和194名感染了艾滋病毒的孕妇。对疫苗在孕妇及其婴儿中的免疫原性，安全性，和疗效进行了评价，直到产后24周。无显著不良反应。来源：http://www.nejm.org/