Circadian Depression Subtype Linked to More Severe Symptoms and Poorer Antidepressant Response
A circadian subtype of depression is associated with earlier disease onset, more severe clinical features, poorer response to commonly prescribed antidepressants, and a distinct genetic risk profile. In a nationwide Australian Genetics of Depression Study, 2,604 participants (23%) met criteria for this subtype, defined by at least three circadian-associated features, […]