Mendelian Randomization

Mediterranean Diet Promising in Lowering Dementia Risk

This entry was posted in Mental Disorders and tagged Dementia Diet Mendelian Randomization Metabolomics on by

A US cohort study revealed genotype-dependent metabolic signatures of cognitive health and support precision nutrition approaches, such as Mediterranean diet for Alzheimer’s disease and related dementias (AD/ADRD) prevention. The study analyzed genetic, plasma metabolomic, and dietary data from 4,215 women and 1,490 men in prospective cohorts. The associations between 57 […]

Gut Microbiota May Have Causal Effects on Non-HDL-c

This entry was posted in Cardiovascular Diseases and tagged Gut Microbiota Mendelian Randomization Metabolomics Metagenomics Non-HDL-c on by

A Chinese cohort study suggested a causal effect of gut microbiota on non-HDL-c and identified 3-indolepropionic acid and N-methyltryptamine as key effectors of gut microbiota to the variation of non-high-density lipoprotein cholesterol (non-HDL-c). The study included a total of 1361 community-dwelling participants without major diseases and free of antibiotics and lipid-lowering […]