Lipids

Genetic Association of Lipid Metabolism with Aortic Aneurysms

This entry was posted in Cardiovascular Diseases and tagged Aortic Aneurysm Genetics Lipids on by

A mendelian randomization (MR) study provides causal evidence for the genetic association of lipid metabolism with aortic aneurysms. By using expression quantitative trait loci (eQTLs) related to drug-target genes and SNPs (single nucleotide polymorphisms) located near or within the drug-target loci associated with low-density lipoprotein cholesterol (LDL-C) as proxies for […]

Causal Effects of Lipids on High BP

This entry was posted in Cardiovascular Diseases and tagged High Blood Pressure Lipids on by

A Mendelian randomization study provides genetic evidence for the causal effects of lipids on blood pressure (BP) indicators. Based on large-scale genome-wide association study summary data, genetically predicted triglycerides (TG) were the most likely causal factor among the major lipids to increase systolic blood pressure (SBP) and diastolic blood pressure […]