2025 Key Updates in the Care of Adults with Congenital Heart Disease

Recent recommendations of the American College of Cardiology/American Heart Association Joint Committee emphasize that adults with congenital heart disease achieve better outcomes when managed at specialized adult congenital heart disease (ACHD) centers with multidisciplinary teams and close involvement of ACHD cardiologists, particularly for patients with moderate or complex anatomy or […]

Smartphone-Based Digital CBT Produces Large and Sustained Benefits for GAD

In a fully remote US randomized clinical trial of 351 adults with generalized anxiety disorder (GAD), smartphone-delivered digital cognitive behavioral therapy (DCBT) produced significantly greater symptom improvement and higher remission rates than an active psychoeducation control, with benefits sustained through 24 weeks. The DCBT mobile application (DaylightRx) for GAD delivered […]

Intensive BP Control Is Effective and Safe Across Low and High DBP Levels

Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]

C-Reactive Protein as a Predictor of CVD Risk

In nearly 450,000 adults without known atherosclerotic cardiovascular disease (CVD), elevated high-sensitivity C-reactive protein (hsCRP) independently predicted major adverse CVD events and mortality, outperformed several conventional risk factors, and significantly improved the Systematic COronary Risk Evaluation 2 (SCORE2)-based risk prediction. In this UK Biobank study, participants had a median age […]

Biological Aging Pace Helps Explain Sex Differences in CVD Risk

In a population-based analysis of 371,032 UK Biobank participants, faster biological aging in males explained a substantial proportion of their higher cardiovascular disease (CVD) risk compared with females, accounting for about 60–68% of the excess risk across major CVD outcomes. Although males and females had similar chronological ages, males consistently […]

Reducing Saturated Fat Intake: Modest Benefits Overall, Meaningful Gains for High-Risk Individuals

A systematic review of 17 randomized trials involving 66,337 adults found that reducing or modifying saturated fat intake offers little or no clinically meaningful benefit over five years for people at low cardiovascular risk, but may lead to important reductions in mortality and major cardiovascular events among those at high […]

Even Moderate Drinking Raises Cancer Risk across Multiple Cancer Types

Even moderate alcohol consumption was consistently linked to a higher risk of multiple cancers, with clear dose–response relationships showing that risk rises with greater frequency and quantity of drinking. In this systematic review of 62 U.S.-based studies, alcohol use was most strongly associated with increased risks of breast, colorectal, and […]

Gradual Antidepressant Tapering With Therapy Reduced Relapse Risk

Slow tapering with psychological support is just as effective as continuing antidepressants—and clearly safer than abrupt or rapid discontinuation—in preventing relapse among people whose depression is in remission. In this systematic review and network meta-analysis of 76 trials including 17,379 adults with remitted depression or anxiety, several strategies outperformed abrupt […]

Corticosteroids Reduce Short-Term Deaths in Severe Pneumonia and ARDS

Adjunct low-dose, short-course corticosteroids probably reduce short-term mortality in adults with severe pneumonia or acute respiratory distress syndrome (ARDS), according to a review of 20 randomized trials involving 3459 participants. Drawing from major medical databases through September 2025, the analysis found that corticosteroids (3 mg/kg of body weight per day […]

Ultra-Processed Foods: A Key Driver of Modern Health Problems

A growing body of evidence shows that ultra-processed foods are displacing traditional, whole-food diets worldwide and driving major diet-related chronic diseases. Drawing on decades of dietary surveys, global sales data, cohort studies, randomized trials, and mechanistic research, this first paper in a three-part Lancet Series reports that ultra-processed foods have […]