CETP Gene Variants Not Associated with CVD Risk

A prospective biobank study concluded that genetic variants of cholesteryl ester transfer protein (CETP) were associated with altered high-density lipoprotein (HDL) metabolism but not lower low-density lipoprotein (LDL) cholesterol levels and had no significant association with risk for cardiovascular disease (CVD). The study included 151 217 individuals aged 30 to 79 […]


Lifestyle Modification Reduced Diabetes Incidence

A meta-analysis of randomized clinical trials concluded that healthy lifestyle modifications (LSM, eating healthier diets and exercising) successfully reduced diabetes incidence and sustained for several years in adults at risk for diabetes. The analysis included 43 studies published between January 1, 1990, and January 1, 2015; 49 029 participants at risk […]


PCI Not Effective in Stable Angina

A blinded, multicenter randomized trial of percutaneous coronary intervention (PCI) versus a sham procedure for angina relief in the UK revealed that in patients with medically treated angina and severe coronary stenosis, PCI did not increase exercise time or improve symptoms. 230 patients with ischemic symptoms and severe (≥70%) single-vessel […]


Genetic Association of Depression with Obesity

An international consortium showed that patients with depression and increased appetite and/or weight (A/W) carried a higher number of genetic risk variants for body mass index (BMI) and levels of C-reactive protein (CRP) and leptin. Data sets were drawn from case-control, cohort, and population-based studies, with established psychiatric diagnoses and […]


Mitochondrial DNA Linked to CVD

In a prospective, population-based cohort analysis, mitochondrial DNA copy number is independently associated with incident cardiovascular disease (CVD) and may have clinical utility in CVD risk classification. The analysis included 21 870 participants (20 163 free from CVD at baseline, mean age 62.4 years, and 54.7% women) from 3 studies with a […]