CRP, LDL Cholesterol, and Lipoprotein(a) Levels Predictive of CVD

A single combined measure of high-sensitivity C-reactive protein (CRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) levels among initially healthy U.S. women predicted incident cardiovascular events over a 30-year period. High-sensitivity CRP, LDL cholesterol, and lipoprotein(a) levels were measured at baseline in 27,939 healthy U.S. women with mean age of 54.7 […]

No Benefit to Stop Beta-Blockers After MI

A French multicenter, open label, randomized, noninferiority trial suggested that interruption of long-term beta-blocker treatment was not found to be noninferior to a strategy of beta-blocker continuation in patients with a history of myocardial infarction (MI). A total of 3698 MI patients (mean age 63.5 years, 17.2% women) were randomized […]

Plant vs Animal Fat on Mortality

A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]

UK T2D Remission Program Findings

An ongoing UK national prospective program shows remission of type 2 diabetes (T2D) outside of research settings, through at-scale service delivery. Between Sept 1, 2020, and Dec 31, 2022, 7540 people (aged 18–65 years diagnosed with T2D within the last 6 years) were referred, 1740 started total diet replacement (TDR) […]

Urine Metals Predictive of CVD and Mortality

A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]

Lipidome Changes Informative of Dietary Fat Quality and Cardiometabolic Risk

A multilipid score (MLS), reflecting the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations, was associated with significantly lower risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). The MLS was based on lipidomics data from a randomized controlled dietary intervention trial, replacing specific […]

Healthy and Sustainable Diet Beneficial for the Prevention of Depression and Anxiety

A prospective UK population-based cohort study suggests that higher adherence to the EAT-Lancet diet is associated with lower risks of incident depression, anxiety and their co-occurrence. The study included 180,446 participants (mean age 56.2, male 46.45%) with 11.62 years of follow-up. The diet largely consists of vegetables, fruits, whole grains, […]

BP Remission in Older Adults with High BP

An observational analysis found that many of older adults with high blood pressure (BP) could be reversed without the intervention of drug treatment in the first few years after diagnosis, and the remission was associated with a lower risk of cardiovascular disease (CVD). The analysis included 2760 participants aged 33–99 […]

Clinical Implications of ECG Abnormalities

A Japanese nationwide cohort study suggested that a diverse array of electrocardiogram (ECG) abnormalities was associated with an increased mortality and cardiovascular disease (CVD). The study included data of 3 698 429 working individuals (mean age, 47.1 years; 66.6% male) from April 1, 2015, to March 31, 2022, 16.8% had 1 minor […]

No Mortality Benefit with Multivitamins Use

A US cohort study concludes that there is no mortality benefit of multivitamin use. The study included 390 124 participants (median age, 61.5 years; 55.4% male) without major chronic diseases from 3 prospective cohort studies. 40.9% of participants were never smokers, and 40.3% were college educated. Among daily multivitamin users, 49.3% […]