Omega-3 Fatty Acids Recommended for Hypertriglyceridemia; Dapagliflozin Effective in HF; Plant‐Based Diets Linked to Lower CVD Risk

A science advisory from the American Heart Association recommended that prescription n-3 fatty acids (eicosapentaenoic acid [EPA]+docosahexaenoic acid [DHA] or EPA-only) at a dose of 4 g/d (>3 g/d total EPA+DHA) are an effective and safe option for reducing triglycerides as monotherapy or as an adjunct to other lipid-lowering agents […]

Lipophilic Statins Linked to Reduced HCC Risk

A nationwide Swedish prospective propensity score–matched cohort study suggests that lipophilic statins were associated with significantly reduced hepatocellular carcinoma (HCC) incidence and mortality. The study included 16 668 adults (8334 who initiated statin use [6554 lipophilic and 1780 hydrophilic] and 8334 nonusers) among 63 279 eligible adults with chronic hepatitis B or […]

Brain and BP

Two US studies showed that more intensive blood pressure (BP) management was associated with less progression of cerebral small vessel ischemic diseaseand a greater decrease in total brain volume; BP patterns in midlife and late life may be associated with differing risks for incident dementia. The substudy of a randomized […]

24-Hour and Nighttime BP Linked to CVD Risk

A longitudinal population-based cohort study showed that higher 24-hour and nighttime blood pressure (BP) measurements were significantly associated with greater risks of death and a composite cardiovascular (CV) outcome. The study included 11 135 adults from Europe, Asia, and South America (median age, 54.7 years, 49.3% women) with baseline observations collected […]

Hemoglobin Levels and Liver Function Markers Linked to AD

Two observational cohort studies revealed that altered levels of hemoglobin and liver function markers were associated with Alzheimer disease (AD). The first study included 12,305 participants without dementia of the population-based Dutch cohort (mean age 64.6 years, 57.7% women). During a mean follow-up of 12.1 years, 1,520 individuals developed dementia, […]

Plant-based Diet Linked to Lower T2D Risk

A systematic review and meta-analysis of prospective observational studies suggested that plant-based dietary patterns were associated with lower risk of type 2 diabetes (T2D), even after adjustment for body mass index. The analysis included 9 studies, totaling 307 099 participants with 23 544 cases of incident T2D. A significant inverse association was […]

Both Systolic and Diastolic Hypertension Contribute to Cardiovascular Risk

A US retrospective cohort study concluded that both systolic and diastolic hypertension contribute significantly to cardiovascular risk. The study included 1.3 million adults in a general outpatient population. The burdens of systolic and diastolic hypertension each independently predicted adverse outcomes. In survival models, a continuous burden of systolic hypertension (≥140 […]

A Healthy Lifestyle Linked to Lower Dementia Risk

A UK retrospective cohort study suggested that a favorable lifestyle was associated with a lower dementia risk among participants with high genetic risk. The study included a total of 196 383 individuals (mean 64.1 years; 52.7% women) from 2006 to 2010, and followed up for 1 545 433 person-years (median follow-up, 8.0 years). […]

Calorie Restriction Reduced Cardiometabolic Risk

A US phase 2, multicenter, randomized controlled trial revealed that 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. From May, 2007, to Feb, 2010, the trial randomly assigned 218 participants  (21–50 years, BMI 22·0–27·9 kg/m 2) to a 25% calorie restriction diet […]