Time Course of LDL-C Linked to CVD Risk

A prospective study suggests that incident cardiovascular disease (CVD) event risk depends on the time course of cumulative prior exposure to low-density lipoprotein cholesterol (LDL-C), the younger the age of exposure accumulation, the greater risk increase. The study included 4,958 asymptomatic adults age 18 to 30 years enrolled from 1985 […]


Timing of Menarche/Menopause and Adverse Pregnancy Outcomes Linked to CVD Risk

Two studies suggest that reproductive life span and adverse pregnancy outcomes are sex-specific risk factors for atherosclerotic cardiovascular disease (CVD) in women. One study included 307 855 women from 12 studies. Overall, the mean ages at menarche, menopause, and reproductive life span were 13.0, 50.2, and 37.2 years, respectively. Pooled analyses […]


Intensive BP Treatment Lowers Risk for Orthostatic Hypotension

A systematic review suggested that Intensive blood pressure (BP)-lowering treatment decreases risk for orthostatic hypotension (OH). OH, before or in the setting of more intensive BP treatment, should not be viewed as a reason to avoid or de-escalate treatment for hypertension. The data were extracted from 5 trials examined BP […]


Early Rhythm-Control Beat Rate-Control in AF

An international, investigator-initiated, parallel-group, open, blinded-outcome-assessment trial concluded that early rhythm-control therapy was associated with a lower risk of cardiovascular (CV) outcomes than usual care among patients with early atrial fibrillation (AF) and CV conditions. A total of 2789 patients who had early AF (diagnosed ≤1 year before enrollment, median […]


State-of-the-Art for Saturated Fats and Health

A state-of-the-art review for saturated fats and health challenges current guideline recommendation to limit dietary saturated fatty acid (SFA) intake. Food sources of SFAs contain different proportions of various fatty acids in addition to other nutrients that can substantially influence their observed physiological and biologic effects. Most recent meta-analyses of […]