Vitamin D3 Reduced Risk of Advanced Cancer

The secondary analysis of a US randomized, double-blind, placebo-controlled clinical trial suggested that vitamin D3 apparently reduced the risk of developing advanced cancer among adults who have normal but not elevated body mass index (BMI). The trial included 25 871 randomized participants (51% female; mean age, 67.1 years), 1617 were diagnosed […]


Finerenone Reduced CV Events and CKD Progression

A randomized, double-blind, placebo-controlled trial in chronic kidney disease (CKD) and type 2 diabetes (T2D) concluded that treatment with finerenone reduced risks of CKD progression and cardiovascular (CV) events. Between September 2015 and June 2018, 5734 patients with CKD and T2D were randomly assigned in a 1:1 ratio to receive […]


Lipid Lowering Beneficial Regardless of Age

A contemporary primary prevention cohort study and a systematic review and meta-analysis showed that older people with elevated LDL cholesterol had higher absolute risk of atherosclerotic cardiovascular disease (CVD), and lipid lowering was as effective in reducing cardiovascular events as it was in younger ones. The cohort study included 13 779 […]


Proinflammatory Diet Linked to CVD

A prospective US study suggests that dietary patterns with a higher proinflammatory potential were associated with higher risk of cardiovascular disease (CVD). The study included 166,234 women and 43,911 men from 3 cohorts, with 5,291,518 person-years of follow-up. The inflammatory potential of diet was evaluated using a food-based empirical dietary […]


Leisure Activity Participation Declines before Developing Dementia

A prospective cohort study in Britain suggests that participation in leisure activities declines in the preclinical phase of dementia. The study included 8,280 participants (69% male, 91% white, mean age 55.8), participation in leisure activities (1997–99 assessment), with 18.0-year follow-up, was not associated with dementia (hazard ratio [HR] 0.92) but […]


Insights from the Global Burden of Disease Study 2019

The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. Five key insights that are important for health, social, and economic development strategies […]