Colchicine Reduced CAD Risk

A meta-analysis of randomized controlled trials concluded that colchicine treatment may reduce the risk of cardiovascular events in patients with coronary artery disease (CAD). The analysis included 5 randomized controlled trials with follow-up duration ≥6 months, comprising a total of 11,790 patients with CAD. Compared with placebo or no treatment, […]


Make Every Bite Count with the Dietary Guidelines

The 2020-2025 Dietary Guidelines for Americans are out. For the first time the Guidelines provide recommendations by life stage, from birth through older adulthood, while focusing on dietary patterns and recognizing that more than half of adults have one or more diet-related chronic diseases. The guidelines: for about the first […]


Conservative Management Safer for Inpatient High BP

A US cohort study suggested that in the absence of evidence of end-organ damage, conservative management of inpatient high blood pressure (BP) was associated with improved outcomes compared with more intensive management. The study included 22 834 adults hospitalized for noncardiovascular diagnoses from January 1 to December 31, 2017 (mean age, […]


Physical Activity Lowered Sedentary Death Risk

A harmonized meta-analysis concluded that longer sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40min of moderate-to-vigorous-intensity physical activity (MVPA) per day attenuate the association between sedentary time and risk of death. The analysis included 44370 middle-aged and older men and women […]


Blood Metabolites Linked to Stroke Risk

Ten metabolites from seven prospective cohort studies were found to be associated with risk of stroke. The studies included 1,791 incident stroke events among 38,797 participants. Independent of traditional risk factors including hypertension, diabetes, smoking, and body mass index, amino acid histidine (hazard ratio [HR] per standard deviation [SD] = […]


Vitamin D3 Reduced Risk of Advanced Cancer

The secondary analysis of a US randomized, double-blind, placebo-controlled clinical trial suggested that vitamin D3 apparently reduced the risk of developing advanced cancer among adults who have normal but not elevated body mass index (BMI). The trial included 25 871 randomized participants (51% female; mean age, 67.1 years), 1617 were diagnosed […]


Finerenone Reduced CV Events and CKD Progression

A randomized, double-blind, placebo-controlled trial in chronic kidney disease (CKD) and type 2 diabetes (T2D) concluded that treatment with finerenone reduced risks of CKD progression and cardiovascular (CV) events. Between September 2015 and June 2018, 5734 patients with CKD and T2D were randomly assigned in a 1:1 ratio to receive […]