Specific Mental Disorders Significantly Increase the Risk of Acute Coronary Syndrome

According to a systematic review and meta-analysis encompassing over 22 million participants and spanning from 1966 to 2021, specific mental disorders have been confirmed to be significantly associated with an increased risk of Acute Coronary Syndrome (ACS). The study screened 3,616 initial records from three major databases, ultimately incorporating 25 […]


US Dietary Guidelines Updated

Released in early 2026, the latest U.S. Dietary Guidelines champion a “real food” approach, advising Americans to prioritize whole foods like vegetables, fruits, proteins, and healthy fats while sharply limiting ultra-processed items, added sugars, and artificial additives. This update introduces significant shifts, including a higher daily protein recommendation, a move […]


Prediabetes Remission Confers Long-Term Protection against CVD

Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]


2025 Key Updates in the Care of Adults with Congenital Heart Disease

Recent recommendations of the American College of Cardiology/American Heart Association Joint Committee emphasize that adults with congenital heart disease achieve better outcomes when managed at specialized adult congenital heart disease (ACHD) centers with multidisciplinary teams and close involvement of ACHD cardiologists, particularly for patients with moderate or complex anatomy or […]


Smartphone-Based Digital CBT Produces Large and Sustained Benefits for GAD

In a fully remote US randomized clinical trial of 351 adults with generalized anxiety disorder (GAD), smartphone-delivered digital cognitive behavioral therapy (DCBT) produced significantly greater symptom improvement and higher remission rates than an active psychoeducation control, with benefits sustained through 24 weeks. The DCBT mobile application (DaylightRx) for GAD delivered […]


Intensive BP Control Is Effective and Safe Across Low and High DBP Levels

Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]


C-Reactive Protein as a Predictor of CVD Risk

In nearly 450,000 adults without known atherosclerotic cardiovascular disease (CVD), elevated high-sensitivity C-reactive protein (hsCRP) independently predicted major adverse CVD events and mortality, outperformed several conventional risk factors, and significantly improved the Systematic COronary Risk Evaluation 2 (SCORE2)-based risk prediction. In this UK Biobank study, participants had a median age […]


Biological Aging Pace Helps Explain Sex Differences in CVD Risk

In a population-based analysis of 371,032 UK Biobank participants, faster biological aging in males explained a substantial proportion of their higher cardiovascular disease (CVD) risk compared with females, accounting for about 60–68% of the excess risk across major CVD outcomes. Although males and females had similar chronological ages, males consistently […]