Healthy Lifestyle May Lower Genetic Cancer Risk

The analysis of genetic and lifestyle factors with cancer incidence in a general-population cohort suggested that genetic cancer risk may be reduced by adopting a healthy lifestyle. An incidence-weighted overall cancer polygenic risk score (CPRS) was constructed based on 20 cancer site-specific polygenic risk scores. Lifestyle was determined according to […]


ARBs May Be Safer Than ACE Inhibitors

A retrospective, new-user comparative cohort study revealed that angiotensin receptor blockers (ARBs) do not differ statistically significantly in effectiveness at the class level compared with ACE (angiotensin-converting enzyme) inhibitors as first-line treatment for high blood pressure but present a better safety profile. The study included all patients with high blood […]


Diagnosis and Management of Myocarditis in Children

A scientific statement from the American Heart Association has been released for the diagnosis and management of myocarditis in children. Myocarditis remains a clinical challenge in pediatrics. Originally, it was recognized at autopsy before the application of endomyocardial biopsy, which led to a histopathology-based diagnosis. Given the invasive and low-sensitivity […]


Meal-Induced Inflammation

A UK single-arm dietary intervention study suggests that postprandial inflammation is largely driven by acute elevations in circulating triglyceride (TG). Glycoprotein acetylation (GlycA) after mixed meals may be a promising candidate biomarker for assessing the food-induced inflammatory response within typical dietary habits. The study included 1002 healthy adults aged 18–65 […]


A Novel Circulating MicroRNA for Myocarditis Diagnosis

A novel microRNA has been identified in mice and humans with myocarditis, and that the human homologue could be used to distinguish patients with myocarditis from those with myocardial infarction. The human homologue, designated hsa-miR-Chr8:96, was identified in four independent cohorts of patients with myocarditis. The area under the receiver-operating-characteristic […]


2021 Guideline for the Secondary Prevention of Stroke

The 2021 secondary stroke prevention guideline from the American Heart Association/American Stroke Association: 1. Recommendations for the diagnostic workup to define ischemic stroke etiology. 2. Management of vascular risk factors remains extremely important, including (but not limited to) diabetes, smoking cessation, lipids, and especially hypertension. 3. Lifestyle factors: Low-salt and […]


Medication May Be Offered for Mild High Blood Pressure

Both a scientific statement from the American Heart Association and an individual participant-level data meta-analysis support that pharmacological blood pressure (BP) lowering is effective for primary and secondary prevention of major cardiovascular disease (CVD), even at BP levels currently not considered for treatment. The statement provides evidence suggesting that in […]