Immune-Mediated Diseases Linked to Cancer Risks

The post hoc analysis of a UK prospective cohort study suggested that immune-mediated diseases were associated with risk of cancer at the local and systemic levels. The analysis included 478 753 participants (mean age, 56.4 years; 54% female) between 2006 and 2010, with follow-up through 2019. During 4 600 460 person-years of follow-up, […]


Exercise-Induced Premature Ventricular Contractions Prognostic

A retrospective cohort study concluded that high-grade exercise-induced premature ventricular contractions (PVCs) occurring during recovery were associated with long-term risk of cardiovascular mortality in asymptomatic individuals, but not PVCs occurring only during exercise. The study included a total of 5,486 asymptomatic individuals with a mean age of 45.4 years and […]


Sodium and Potassium Intakes Linked to Cardiovascular Risk

Higher sodium and lower potassium intakes, as measured in multiple 24-hour urine samples, were associated in a dose–response manner with a higher cardiovascular risk in a pooled random-effects meta-analysis of individual-participant data from six prospective cohorts of generally healthy adults in the US. The analysis included 10,709 participants, mean age […]


Mental Stress–Induced Myocardial Ischemia Prognostic

Pooled analysis of 2 US prospective cohort studies of patients with stable coronary heart disease (CHD) suggested that myocardial ischemia with mental stress, compared with no ischemia with mental stress, was significantly associated with an increased risk of cardiovascular (CV) death or nonfatal myocardial infarction (MI). The analysis included 918 […]


BP and Heart Rate Patterns Prognostic

A longitudinal cohort study in Italy suggested that non-dipping and reverse dipping blood pressure (BP) patterns are associated with an increased prevalence of cardiac autonomic neuropathy and reduced survival. The study recruited 349 diabetic patients (52% women, age 57.1±11.9 y, BMI 29.4±5.9 kg/m2, HbA1c 8.6±2.1%, 284 with type 2 diabetes) […]


MIND Diet Linked to Better Cognitive Resilience

A US longitudinal clinical-pathologic study revealed that healthy diet is associated with cognitive resilience (defined as performing better than expected given burden of neuropathology) independently of common brain pathology in older adults. The study included 569 decedents with valid dietary data, cognitive testing proximate to death, and complete autopsy data. […]


Cumulative LDL-C Linked to CVD

A pooled US cohorts study suggests that maintaining an optimal level of low-density lipoprotein cholesterol (LDL-C) throughout young adulthood and middle age can minimize the lifetime risk for atherosclerotic cardiovascular disease (CVD). The study included data of 18 288 participants (mean age 56.4, 56.4% women) collected from 1971 to 2017 from […]


Healthy Sleep Patterns Linked to Lower Arrhythmias Risk

A prospective observational study indicated that a healthy sleep pattern was associated with lower risks of atrial fibrillation/flutter (AF) and bradyarrhythmia, independent of traditional risk factors, and the association of the healthy sleep pattern with the risk of AF was stronger among those with a lower genetic risk of AF. […]