Lifestyle Intervention Effective in Preventing CVD

A multi-domain lifestyle intervention among older Finnish adults was effective in preventing cerebrovascular events and total cardiovascular disease (CVD) events among those with a history of CVD. A total of 1259 individuals aged 60–77 years with elevated risk for dementia were randomized (1:1) to a 2-year multi-domain intervention with diet, […]


How to Stop Antidepressants in A Tolerable Way

Guidance on how to stop antidepressants in a tolerable way has been produced by the Royal College of Psychiatrists. Prescriptions of antidepressants, primarily selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, has steadily increased over recent years. There is ongoing debate about their benefits and increasing recognition of […]


Resting Heart Rate Linked to Dementia

A Swedish population-based cohort study suggested that higher resting heart rate (RHR) was associated with increased risk for dementia and faster cognitive decline independent of cardiovascular disease (CVD) in a general population of elderly people. The study included 2147 participants (age≥60) who were free of dementia and regularly followed from […]


Immune-Mediated Diseases Linked to Cancer Risks

The post hoc analysis of a UK prospective cohort study suggested that immune-mediated diseases were associated with risk of cancer at the local and systemic levels. The analysis included 478 753 participants (mean age, 56.4 years; 54% female) between 2006 and 2010, with follow-up through 2019. During 4 600 460 person-years of follow-up, […]


Exercise-Induced Premature Ventricular Contractions Prognostic

A retrospective cohort study concluded that high-grade exercise-induced premature ventricular contractions (PVCs) occurring during recovery were associated with long-term risk of cardiovascular mortality in asymptomatic individuals, but not PVCs occurring only during exercise. The study included a total of 5,486 asymptomatic individuals with a mean age of 45.4 years and […]


Sodium and Potassium Intakes Linked to Cardiovascular Risk

Higher sodium and lower potassium intakes, as measured in multiple 24-hour urine samples, were associated in a dose–response manner with a higher cardiovascular risk in a pooled random-effects meta-analysis of individual-participant data from six prospective cohorts of generally healthy adults in the US. The analysis included 10,709 participants, mean age […]


Mental Stress–Induced Myocardial Ischemia Prognostic

Pooled analysis of 2 US prospective cohort studies of patients with stable coronary heart disease (CHD) suggested that myocardial ischemia with mental stress, compared with no ischemia with mental stress, was significantly associated with an increased risk of cardiovascular (CV) death or nonfatal myocardial infarction (MI). The analysis included 918 […]