Light Exposure Timing Influences Metabolism

A randomized, controlled, crossover trial in overweight insulin-resistant volunteers in the Netherlands suggested that in contrast to Dim day–Bright evening condition, Bright day–Dim evening condition mostly elicited favorable metabolic outcomes. The trial included 14 overweight 40–75 years male and female, insulin-resistant volunteers between July 2018 and November 2019. Participants were randomly […]


Causal Alcohol-Cancer Link Modified by Genotype

A prospective study in China revealed that certain genotypes of alcohol metabolism might reduce or exacerbate the effects of alcohol on several cancers. Aldehyde dehydrogenase 2 (ALDH2)-rs671 G>A and alcohol dehydrogenase 1B (ADH1B)-rs1229984 G>A were genotyped in 150 722 adults, enrolled from 10 areas in China from 2004 to 2008. […]


Lifestyle Intervention Effective in Preventing CVD

A multi-domain lifestyle intervention among older Finnish adults was effective in preventing cerebrovascular events and total cardiovascular disease (CVD) events among those with a history of CVD. A total of 1259 individuals aged 60–77 years with elevated risk for dementia were randomized (1:1) to a 2-year multi-domain intervention with diet, […]


How to Stop Antidepressants in A Tolerable Way

Guidance on how to stop antidepressants in a tolerable way has been produced by the Royal College of Psychiatrists. Prescriptions of antidepressants, primarily selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, has steadily increased over recent years. There is ongoing debate about their benefits and increasing recognition of […]


Resting Heart Rate Linked to Dementia

A Swedish population-based cohort study suggested that higher resting heart rate (RHR) was associated with increased risk for dementia and faster cognitive decline independent of cardiovascular disease (CVD) in a general population of elderly people. The study included 2147 participants (age≥60) who were free of dementia and regularly followed from […]


Immune-Mediated Diseases Linked to Cancer Risks

The post hoc analysis of a UK prospective cohort study suggested that immune-mediated diseases were associated with risk of cancer at the local and systemic levels. The analysis included 478 753 participants (mean age, 56.4 years; 54% female) between 2006 and 2010, with follow-up through 2019. During 4 600 460 person-years of follow-up, […]


Exercise-Induced Premature Ventricular Contractions Prognostic

A retrospective cohort study concluded that high-grade exercise-induced premature ventricular contractions (PVCs) occurring during recovery were associated with long-term risk of cardiovascular mortality in asymptomatic individuals, but not PVCs occurring only during exercise. The study included a total of 5,486 asymptomatic individuals with a mean age of 45.4 years and […]