Statin Benefits Modest

A systematic review and meta-analysis suggests that the absolute benefits of statins are modest and may not be strongly mediated through the degree of low-density lipoprotein cholesterol (LDL-C) reduction. The analysis included 21 randomized clinical trials that examined the effectiveness of statins in reducing total mortality and cardiovascular outcomes with […]


Intensive BP Control Increased Brain Blood Flow

A substudy of the randomized clinical trial compared intensive vs standard systolic blood pressure (SBP) control revealed that the intensive BP treatment was associated with increased, rather than decreased, cerebral perfusion. The substudy included 547 participants (mean age 67.5 years, 40.0% women) with whole-brain cerebral blood flow (CBF) measured at […]


Traditional Dietary Advice Preferred in Non-Constipated IBS

An UK randomized trial revealed that traditional dietary advice (TDA), low FODMAP diet (LFD) and gluten-free diet (GFD) are all effective approaches in non-constipated irritable bowel syndrome (IBS), but TDA is the most patient-friendly in terms of cost and convenience. A total of 99 patients with non-constipated IBS completed the […]


Sodium-containing Acetaminophen Linked to CVD Risk

Two UK cohort studies among individuals with and without high blood pressure (HBP) found that the initiation of sodium-containing acetaminophen was associated with a significant higher risk of incident cardiovascular disease (CVD, including myocardial infarction, stroke, and heart failure) and all-cause mortality than non-sodium-containing acetaminophen. The studies used marginal structural […]


Leg Muscle Preactivation and Tensing Mitigate initial Orthostatic Hypotension

A Canadian study demonstrated that preactivating lower body muscle (PREACT) and leg crossing with muscle tensing (TENSE) after standing attenuates symptoms and blood pressure (BP) drop of initial orthostatic hypotension (IOH) upon standing. The study included 24 female IOH participants (mean ± SD: 32 ± 8 years) completed 3 sit-to-stand […]


Light Exposure Timing Influences Metabolism

A randomized, controlled, crossover trial in overweight insulin-resistant volunteers in the Netherlands suggested that in contrast to Dim day–Bright evening condition, Bright day–Dim evening condition mostly elicited favorable metabolic outcomes. The trial included 14 overweight 40–75 years male and female, insulin-resistant volunteers between July 2018 and November 2019. Participants were randomly […]


Causal Alcohol-Cancer Link Modified by Genotype

A prospective study in China revealed that certain genotypes of alcohol metabolism might reduce or exacerbate the effects of alcohol on several cancers. Aldehyde dehydrogenase 2 (ALDH2)-rs671 G>A and alcohol dehydrogenase 1B (ADH1B)-rs1229984 G>A were genotyped in 150 722 adults, enrolled from 10 areas in China from 2004 to 2008. […]