A longitudinal study in the US revealed that low-density lipoprotein cholesterol (LDL-C) and non–high-density lipoprotein cholesterol (HDL-C) ≥160 mg/dL were independently associated with a 50% to 80% increased relative risk of cardiovascular disease (CVD) mortality in a low risk cohort with long-term follow-up. The study included 36 375 participants (72% […]
A prospective US cohort study and meta-analysis suggested that both high and low percentages of carbohydrate diets were associated with increased mortality, with minimal risk observed at 50–55% carbohydrate intake. The association was modified by the source of food, with higher mortality when carbohydrates were exchanged for animal-derived fat or […]
The secondary analysis of a US community-based cohort study suggested that right ventricular (RV) dysfunction played an important and underrecognized role in the progression to heart failure (HF). This study included 1004 elderly participants (mean age 76 years, 385 men, and 121 black) who underwent both 3-dimensional and 2-dimensional RV […]
The ongoing prospective urban rural epidemiology study in 21 countries suggested that sodium intake was associated with cardiovascular disease (CVD) and strokes in communities where mean intake was greater than 5 g/day, and CVD decreased with increasing potassium intake in all countries. The study included 95 767 participants in 369 communities […]
Canadian professional groups recommended deprescribing proton pump inhibitors (PPIs) in adults who have completed a minimum of 4 weeks of PPI treatment for heartburn or mild to moderate gastroesophageal reflux disease or esophagitis, and whose symptoms are resolved. Deprescirbing by decreasing the daily dose or stopping and changing to on-demand […]
A French prospective population-based cohort study suggests that healthy diet by following dietary recommendations could significantly contribute to cancer prevention. The study investigated the associations between several nutritional scores and overall, breast, prostate, and colorectal cancer risk in a large prospective population-based cohort. The study included 41,543 participants aged ≥40 […]
A meta-analysis revealed that there is a consistent relative risk reduction in major vascular events per further reduction in low-density lipoprotein cholesterol (LDL-C) in patient populations starting as low as a median of 1.6 mmol/L (63 mg/dL) and achieving levels as low as a median of 0.5 mmol/L (21 mg/dL), […]
An US prospective cohort study revealed that orthostatic hypotension (OH) in midlife was independently associated with incident dementia and ischemic stroke. The study included 11,709 participants without a history of coronary heart disease or stroke at the baseline examination (1987–1989, mean age 54). OH was defined as a drop in […]
A randomized noninferiority trial in Australia suggested that intermittent energy restriction is an effective alternative diet strategy for the reduction of hemoglobin A1c (HbA1c) level comparable to continuous energy restriction in patients with type 2 diabetes (T2D), and it may be superior to continuous energy restriction for weight loss. The […]
An UK study found that bolus water drinking is superior to other nonpharmacological interventions for older people with orthostatic hypotension (OH). A total of 150 orthostatic challenges were performed in 25 older people (age 60–92 years). The response rate (of participants whose systolic blood pressure [SBP] drop improved by ≥10 […]