An international, multicenter, randomized trial concluded that the use of risk assessment with multiparametric magnetic resonance imaging (MRI) and MRI-targeted biopsy was superior to standard transrectal ultrasonography–guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who had not undergone biopsy. A total of 500 men underwent […]
A multi-center registry in the US revealed that myocarditis associated with immune checkpoint inhibitors (ICI) may occur early, has a malignant course and may respond to higher doses of steroids. The initial 35 cases were diagnosed between November 2013 and July 2017, with an incidence of 1.9% and median onset […]
Growing body of evidence supports that increasing adiposity has a detrimental association with cardiovascular disease (CVD) and longevity. The association of body mass index (BMI) with CVD appeared more susceptible to confounding due to pre-existing comorbidities. Associations of waist circumference, waist-to-hip ratio, waist-to-height ratio, and percentage body fat mass with […]
A randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, showed that a select group of short-chain fatty acid (SCFA)-producing strains of the gut microbiota was promoted by dietary fibers, and correlated with improved blood-glucose regulation in type 2 diabetes mellitus (T2D). The improvement in hemoglobin […]
A randomized chemoprevention study in the US found evidence that calcium and vitamin D supplementation increased the risk of sessile serrated adenomas or polyps (SSA/Ps), precursor lesions for colorectal cancer. A total of 2259 participants with one or more adenoma at baseline were randomized to receive 1200 mg/day of elemental calcium, […]