Findings from a prospective cohort study challenge current global dietary guidelines. A total of 135 335 individuals aged 35 to 70 years without cardiovascular disease (CVD) were enrolled between Jan 1, 2003, and March 31, 2013 from 613 communities in 18 low-income, middle-income, and high-income countries in seven geographical regions globally. […]
A randomized, double-blind trial of canakinumab targeting interleukin-1β innate immunity pathway revealed a significantly lower rate of recurrent cardiovascular events in patients of myocardial infarction (MI). The trial included 10,061 patients with previous MI and a high-sensitivity C-reactive protein （hsCRP） level of 2 mg or more per liter. Canakinumab (at […]
Patient-reported outcomes among participants who received intensive BP treatment were similar to those among participants who received standard treatment. A total of 9361 participants with hypertension at high risk for cardiovascular disease were randomly assigned to a systolic blood-pressure (SBP) target of less than 120 mm Hg or 140 mm […]
A prospective cohort study of a general Japanese population demonstrated a significant independent association between increased day-to-day blood pressure variability (BPV) measured with home blood pressure monitoring and risk of dementia. The study included 1674 community-dwelling Japanese elderly without dementia, ≥60 years of age, and followed up for 5 years […]
A study revealed that estimated sodium intake (ESI) >3.7 g/day is associated with adverse cardiac remodeling and function. The study performed speckle-tracking analysis on echocardiograms with available urinary sodium data (N = 2,996). Mean age of participants was 49 ± 14 years, 57% were female, 50% were African American, and […]